Bioinspired Collagen Scaffolds in Cranial Bone Regeneration: From Bedside to Bench.
Bioinspired Collagen Scaffolds in Cranial Bone Regeneration: From Bedside to Bench.
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DOI：
10.1002/adhm.201700232
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发表时间：
2017-09
影响因子：
10
通讯作者：
Volpicelli EJ
中科院分区：
文献类型：
--
作者：
Lee JC;Volpicelli EJ
颅骨缺损是常见的重建困境继发于各种病因，包括创伤性脑损伤，脑血管疾病，肿瘤切除术，先天性异常。颅骨重建通常是为了保护大脑，恢复轮廓以获得心理健康，以及使大面积颅骨缺损患者常见的神经功能障碍正常化。目前使用自体移植物、同种异体移植物或异体材料进行重建的方法具有每种材料所特有的显著缺点。广泛的医学相关性和对更好的临床解决方案的需求相结合，使得颅骨骨骼的缺陷成为开发以颅骨为重点的再生策略的理想目标。随着对组织特异性细胞外基质的指导性质的更好理解以及材料科学中精确纳米级调制的出现，再生医学的策略已经在范式上发生了转变。以前被认为是干细胞和生长因子的简单载体，越来越多的证据表明存在指导祖细胞谱系特异性分化和组织再生的差异材料。在这项工作中，我们回顾了颅骨重建的临床挑战，骨的解剖学和生理学，以及细胞外基质启发的胶原基材料，这些材料已经过体内颅骨缺损愈合测试。
Calvarial defects are common reconstructive dilemmas secondary to a variety of etiologies including traumatic brain injury, cerebrovascular disease, oncologic resection, and congenital anomalies. Reconstruction of the calvarium is generally undertaken for the purposes of cerebral protection, contour restoration for psychosocial well-being, and normalization of neurological dysfunction frequently found in patients with massive cranial defects. Current methods for reconstruction using autologous grafts, allogeneic grafts, or allo-plastic materials have significant drawbacks that are unique to each material. The combination of wide medical relevance and the need for a better clinical solution render defects of the cranial skeleton an ideal target for development of regenerative strategies focused on calvarial bone. With the improved understanding of the instructive properties of tissue-specific extracellular matrices and the advent of precise nanoscale modulation in materials science, strategies in regenerative medicine have shifted in paradigm. Previously considered to be simple carriers of stem cells and growth factors, increasing evidence exists for differential materials directing lineage specific differentiation of progenitor cells and tissue regeneration. In this work, we review the clinical challenges for calvarial reconstruction, the anatomy and physiology of bone, and extracellular matrix-inspired, collagen-based materials that have been tested for in vivo cranial defect healing.
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