Associations of Reading Efficiency with White Matter Properties of the Cerebellar Peduncles in Children.
Associations of Reading Efficiency with White Matter Properties of the Cerebellar Peduncles in Children.
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DOI：
10.1007/s12311-020-01162-2
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Feldman HM
中科院分区：
文献类型：
--
作者：
Bruckert L;Travis KE;Mezer AA;Ben-Shachar M;Feldman HM
儿童的阅读与小脑脚的微观结构特性有关，小脑脚是连接小脑和大脑的白色物质通路。在这项研究中，我们使用了两种独立的神经影像学方法来评估小脑脚的哪些特征与阅读相关。对23名8岁儿童的文字阅读效率进行了评估，并使用弥散MRI（dMRI）和定量T1弛豫法（qT 1）进行成像。我们分割了上级（SCP），中，下小脑脚和提取两个指标：分数各向异性（FA）从dMRI和R1从qT 1。在左侧和右侧SCP中，tract-FA与tract-R1显著相关（左侧：rP（21）= 0.63，右侧：rP（21）= 0.76，p ≤ 0.001），表明这些脚的FA至少部分指示髓鞘含量。在其他小脑脚中，FA束和R1束不相关。阅读效率与左侧（rP（21）=-0.43，p = 0.040）和右侧SCP（rP（21）=-0.37，p = 0.079）的trac-FA呈负相关。阅读效率与SCP中的tract-R1不相关。阅读效率与tract-FA呈负相关，而阅读效率与tract-R1缺乏相关性，这表明儿童阅读技能的个体差异与小脑和大脑之间的信息流有关，而不是与髓鞘含量有关。
Reading in children has been associated with microstructural properties of the cerebellar peduncles, the white matter pathways connecting the cerebellum to the cerebrum. In this study, we used two independent neuroimaging modalities to assess which features of the cerebellar peduncles would be associated with reading. Twenty-three 8-year-old children were evaluated on word reading efficiency and imaged using diffusion MRI (dMRI) and quantitative T1 relaxometry (qT1). We segmented the superior (SCP), middle, and inferior cerebellar peduncles and extracted two metrics: fractional anisotropy (FA) from dMRI and R1 from qT1. Tract-FA was significantly correlated with tract-R1 in left and right SCPs (left: rP(21) = .63, right: rP(21) = .76, p ≤ .001) suggesting that FA of these peduncles, at least in part, indexed myelin content. Tract-FA and tract R1 were not correlated in the other cerebellar peduncles. Reading efficiency negatively correlated with tract-FA of the left (rP(21) = −.43, p = .040) and right SCP (rP(21) = −.37, p = .079). Reading efficiency did not correlate with tract-R1 in the SCPs. The negative association of reading efficiency with tract-FA and the lack of association of reading efficiency with tract-R1 implicate properties other than myelin content as relevant to the information flow between the cerebellum and the cerebrum for individual differences in reading skills in children.
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影响因子：
3.8
作者：
Dodson CK;Travis KE;Borchers LR;Marchman VA;Ben-Shachar M;Feldman HM
通讯作者：
Feldman HM
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2.6
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3.5
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通讯作者：
Timmann, Dagmar