Spatiotemporal patterns of Gem expression after rat spinal cord injury
Spatiotemporal patterns of Gem expression after rat spinal cord injury
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大鼠脊髓损伤后 Gem 表达的时空模式
DOI：
10.1016/j.brainres.2013.04.023
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发表时间：
2013-06
期刊：
影响因子：
2.9
通讯作者：
Long, Long
中科院分区：
文献类型：
--
作者：
Zhang, Feng;Cao, Jianhua;Yu, Xiaowei;Sun, Binbin;Ding, Tao;Li, Ming;Li, Debao;Wu, Hao;Long, Long
Gem is an atypical protein of the Ras superfamily that plays a role in regulating voltage-gated Ca2+channels and cytoskeletal reorganization. To elucidate the certain expression and biological function in central nervous system (CNS), we performed an acute spinal cord contusion injury model in adult rats. Western blot analysis showed a marked up-regulation of Gem after spinal cord injury (SCI). Immunohistochemistry revealed wide distribution of Gem in spinal cord, including neurons and glial cells. Double immunofluorescent staining for proliferating cell nuclear antigen (PCNA) and phenotype-specific markers indicated increases of Gem expression in proliferating microglia and astrocytes. Our data suggest that Gem may be implicated in the proliferation of microglia and astrocytes after SCI.
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DOI：
10.1080/09638280110110640
发表时间：
2002-01
期刊：
The Lancet
影响因子：
--
作者：
J. Mcdonald;C. Sadowsky
通讯作者：
J. Mcdonald;C. Sadowsky
影响因子：
56.9
作者：
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通讯作者：
KELLY, K
影响因子：
3.2
作者：
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通讯作者：
Zhiqiang Liu;Dongling Wang;Bai Shao;Xiaohong Wu;Jian Xu;Q. Lu;Yidan Wang;Chunmiao Li;A. She
影响因子：
4.8
作者：
Anne Splingard;J. Ménétrey;M. Perderiset;J. Cicolari;Karine Regazzoni;F. Hamoudi;L. Cabanié;Ahmed El Marjou;Amber L. Wells;A. Houdusse;J. de Gunzburg
通讯作者：
Anne Splingard;J. Ménétrey;M. Perderiset;J. Cicolari;Karine Regazzoni;F. Hamoudi;L. Cabanié;Ahmed El Marjou;Amber L. Wells;A. Houdusse;J. de Gunzburg
影响因子：
64.8
作者：
Béguin, P;Nagashima, K;Seino, S
通讯作者：
Seino, S