Manipulation of Host Microtubule Networks by Viral Microtubule-Associated Proteins.
Manipulation of Host Microtubule Networks by Viral Microtubule-Associated Proteins.
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DOI：
10.3390/v14050979
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发表时间：
2022-05-06
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影响因子：
--
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中科院分区：
文献类型：
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不同的DNA和RNA病毒利用细胞骨架网络有效地进入、复制和离开宿主细胞，同时逃避宿主免疫反应。众所周知，微管（MT）网络通常被病毒劫持，在进入细胞后运输到复制位点，并促进从细胞中排出。然而，越来越多的证据表明，MT网络也是宿主对感染免疫反应的关键调节因子。同时，病毒已经获得了操纵和/或篡夺MT网络以逃避这些免疫反应的机制。大多数病毒与MT网络相互作用的核心是直接或间接结合MT的病毒编码的微管相关蛋白（MAP）。这些MAP与MT和其他病毒或细胞MAP相关联以调节MT网络的各个方面，包括MT动力学、经由马达蛋白如驱动蛋白和动力蛋白的MT依赖性转运以及先天免疫应答的MT依赖性调节。在这篇综述中，我们研究了病毒MAP与MT网络的相互作用如何促进病毒复制和免疫逃避。
Diverse DNA and RNA viruses utilize cytoskeletal networks to efficiently enter, replicate, and exit the host cell, while evading host immune responses. It is well established that the microtubule (MT) network is commonly hijacked by viruses to traffic to sites of replication after entry and to promote egress from the cell. However, mounting evidence suggests that the MT network is also a key regulator of host immune responses to infection. At the same time, viruses have acquired mechanisms to manipulate and/or usurp MT networks to evade these immune responses. Central to most interactions of viruses with the MT network are virally encoded microtubule-associated proteins (MAPs) that bind to MTs directly or indirectly. These MAPs associate with MTs and other viral or cellular MAPs to regulate various aspects of the MT network, including MT dynamics, MT-dependent transport via motor proteins such as kinesins and dyneins, and MT-dependent regulation of innate immune responses. In this review, we examine how viral MAP interactions with the MT network facilitate viral replication and immune evasion.
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影响因子：
3.7
作者：
Haller O;Kochs G;Weber F
通讯作者：
Weber F
影响因子：
12.4
作者：
Canty JT;Tan R;Kusakci E;Fernandes J;Yildiz A
通讯作者：
Yildiz A
影响因子：
3.3
作者：
de Mareuil J;Carre M;Barbier P;Campbell GR;Lancelot S;Opi S;Esquieu D;Watkins JD;Prevot C;Braguer D;Peyrot V;Loret EP
通讯作者：
Loret EP
DOI：
10.1073/pnas.50.2.268
发表时间：
1963-01-01
影响因子：
11.1
作者：
DALES, S
通讯作者：
DALES, S
影响因子：
4.4
作者：
Gawlik K;Gallay PA
通讯作者：
Gallay PA