Hyperactivation of the habenula as a link between depression and sleep disturbance.
Hyperactivation of the habenula as a link between depression and sleep disturbance.
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DOI：
10.3389/fnhum.2013.00826
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发表时间：
2013-12-10
影响因子：
2.9
通讯作者：
Okamoto H
中科院分区：
文献类型：
--
作者：
Aizawa H;Cui W;Tanaka K;Okamoto H
抑郁症经常伴随睡眠障碍，如失眠。抑郁症的睡眠与快速眼动（REM）睡眠的去抑制有关。尽管抑郁症与睡眠障碍同时发生，但抑郁行为和睡眠调节的神经基础仍不清楚。缰核是调节脑干单胺能神经元活动的上丘脑结构。由于影像学研究显示抑郁症患者的缰核中血流增加，因此缰核的过度激活与抑郁症的病理生理学有关。最近的电生理学研究报道了缰结构在REM睡眠调节中的新作用。在这篇文章中，我们提出了可能的细胞机制，可能会引起过度激活的缰神经元和一个假设，在缰回路功能障碍导致抑郁症的行为和睡眠障碍。对具有过度激活的缰核的动物的分析将打开理解缰核在异质性症状中的作用的大门，例如抑郁症中的运动行为减少和REM睡眠改变。
Depression occurs frequently with sleep disturbance such as insomnia. Sleep in depression is associated with disinhibition of the rapid eye movement (REM) sleep. Despite the coincidence of the depression and sleep disturbance, neural substrate for depressive behaviors and sleep regulation remains unknown. Habenula is an epithalamic structure regulating the activities of monoaminergic neurons in the brain stem. Since the imaging studies showed blood flow increase in the habenula of depressive patients, hyperactivation of the habenula has been implicated in the pathophysiology of the depression. Recent electrophysiological studies reported a novel role of the habenular structure in regulation of REM sleep. In this article, we propose possible cellular mechanisms which could elicit the hyperactivation of the habenular neurons and a hypothesis that dysfunction in the habenular circuit causes the behavioral and sleep disturbance in depression. Analysis of the animals with hyperactivated habenula would open the door to understand roles of the habenula in the heterogeneous symptoms such as reduced motor behavior and altered REM sleep in depression.
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DOI：
10.1073/pnas.1018022108
发表时间：
2011-01-11
影响因子：
11.1
作者：
Groth, Rachel D.;Lindskog, Maria;Tsien, Richard W.
通讯作者：
Tsien, Richard W.
影响因子：
34.7
作者：
Hikosaka, Okihide
通讯作者：
Hikosaka, Okihide
影响因子：
3.3
作者：
Kowski, A. B.;Veh, R. W.;Weiss, T.
通讯作者：
Weiss, T.
影响因子：
5.3
作者：
HAUN, F;ECKENRODE, TC;MURRAY, M
通讯作者：
MURRAY, M
影响因子：
4.8
作者：
Haugeto, O;Ullensvang, K;Danbolt, NC
通讯作者：
Danbolt, NC