Neuronal activity in primate prefrontal cortex related to goal-directed behavior during auditory working memory tasks
Neuronal activity in primate prefrontal cortex related to goal-directed behavior during auditory working memory tasks
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灵长类前额叶皮层的神经元活动与听觉工作记忆任务中的目标导向行为相关
DOI：
10.1016/j.brainres.2016.02.010
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发表时间：
2016
期刊：
影响因子：
2.9
通讯作者：
Brosch M
中科院分区：
文献类型：
--
作者：
Huang Y;Brosch M
前额叶皮质(PFC)在目标定向行为中起关键作用，如代表目标相关事件和工作记忆(WM)。然而，PFC这种作用的神经生理学证据主要是通过视觉任务获得的，而很少是通过听觉任务获得的。在本研究中，我们通过在一只猴子执行听觉WM任务时记录左腹外侧PFC听区的局部场电位来测试PFC在听觉目标导向行为中的作用。这些任务由多个事件组成，需要猴子改变其精神状态才能获得奖励。这些事件是听觉和视觉刺激，以及特定的动作。听觉工作记忆中的心理状态是参与任务并持有与任务相关的信息。我们发现，尽管PFC只基于猴子一侧大脑半球的记录，但它代表了对获得奖励很重要的多个事件，包括打开和关闭LED等听觉和视觉刺激，以及条形图触摸。对听觉事件的反应取决于任务和任务的背景。这支持了PFC中的神经元表征是灵活的，并可以与刺激的行为意义相关的观点。我们还发现，在听觉WM中参与任务和持有信息与慢电位的持续变化有关，这两者都是听觉目标导向行为所必需的。我们在单个猴子的单个大脑半球上的研究揭示了PFC在听觉目标定向行为中的作用，类似于视觉目标定向行为中的作用，这表明PFC在目标定向行为中的功能可能在听觉和视觉模式中都是共同的。本文是题为SI：听觉工作记忆的特刊的一部分。
Prefrontal cortex (PFC) has been documented to play critical roles in goal-directed behaviors, like representing goal-relevant events and working memory (WM). However, neurophysiological evidence for such roles of PFC has been obtained mainly with visual tasks but rarely with auditory tasks. In the present study, we tested roles of PFC in auditory goal-directed behaviors by recording local field potentials in the auditory region of left ventrolateral PFC while a monkey performed auditory WM tasks. The tasks consisted of multiple events and required the monkey to change its mental states to achieve the reward. The events were auditory and visual stimuli, as well as specific actions. Mental states were engaging in the tasks and holding task-relevant information in auditory WM. We found that, although based on recordings from one hemisphere in one monkey only, PFC represented multiple events that were important for achieving reward, including auditory and visual stimuli like turning on and off an LED, as well as bar touch. The responses to auditory events depended on the tasks and on the context of the tasks. This provides support for the idea that neuronal representations in PFC are flexible and can be related to the behavioral meaning of stimuli. We also found that engaging in the tasks and holding information in auditory WM were associated with persistent changes of slow potentials, both of which are essential for auditory goal-directed behaviors. Our study, on a single hemisphere in a single monkey, reveals roles of PFC in auditory goal-directed behaviors similar to those in visual goal-directed behaviors, suggesting that functions of PFC in goal-directed behaviors are probably common across the auditory and visual modality.This article is part of a Special Issue entitled SI: Auditory working memory.
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空间和非空间听觉任务中工作记忆负荷对慢脑电位的调节
影响因子：
2.6
作者：
P. Rämä;L. Paavilainen;Irina Anourova;K. Alho;K. Reinikainen;S. Sipilä;S. Carlson
通讯作者：
S. Carlson
影响因子：
2.5
作者：
Asaad, WF;Rainer, G;Miller, EK
通讯作者：
Miller, EK
DOI：
10.1073/pnas.0907248106
发表时间：
2009-11-24
影响因子：
11.1
作者：
Cohen, Y. E.;Russ, B. E.;Nitecki, R.
通讯作者：
Nitecki, R.
前额皮质工作记忆的神经机制。
DOI：
--
发表时间：
2008
期刊：
影响因子：
--
作者：
Funahashi;S.
通讯作者：
S.
影响因子：
5.3
作者：
Brosch, M;Selezneva, E;Scheich, H
通讯作者：
Scheich, H