Role of Inflammatory Risk Factors in the Pathogenesis of Streptococcus pneumoniae.
Role of Inflammatory Risk Factors in the Pathogenesis of Streptococcus pneumoniae.
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DOI：
10.3389/fimmu.2018.02275
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发表时间：
2018
影响因子：
7.3
通讯作者：
Khan MN
中科院分区：
文献类型：
--
作者：
Sohail I;Ghosh S;Mukundan S;Zelewski S;Khan MN
肺炎链球菌(Spn)是人类鼻咽(NP)的定殖体，可引起包括中耳炎、肺炎、败血症和脑膜炎在内的多种人类感染。NP是一个免疫允许性部位，允许共生细菌持续存在。急性或慢性呼吸道炎症是Spn感染表现的重要危险因素。由上呼吸道病毒感染引起的炎症状态或过敏性哮喘和慢性阻塞性肺疾病(COPD)等呼吸系统疾病与呼吸道炎症和组织损伤的调节失调有关，从而危及呼吸屏障的完整性。这些免疫事件促进细菌生长，导致Spn扩散和侵入血液。因此，抑制炎症和恢复呼吸屏障的完整性可以遏制在炎症性疾病背景下表现的Spn感染。所获得的知识可用于设计新的治疗干预措施，以避免Spn细菌感染。
Streptococcus pneumoniae (Spn) is a colonizer of the human nasopharynx (NP), causing a variety of infections in humans including otitis media, pneumonia, sepsis, and meningitis. The NP is an immune permissive site which allows for the persistence of commensal bacteria. Acute or chronic respiratory airway inflammation constitutes a significant risk factor for the manifestation of Spn infections. The inflammatory conditions caused by an upper respiratory viral infection or respiratory conditions such as allergic asthma and chronic obstructive pulmonary disorders (COPDs) are implicated in the dysregulation of airway inflammation and tissue damage, which compromise the respiratory barrier integrity. These immune events promote bacterial outgrowth leading to Spn dissemination and invasion into the bloodstream. Therefore, suppression of inflammation and restoration of respiratory barrier integrity could contain Spn infections manifesting in the backdrop of an inflammatory disease condition. The gained knowledge could be harnessed in the design of novel therapeutic interventions to circumvent Spn bacterial infections.
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影响因子：
2.9
作者：
Agarwal, Ritesh;Gupta, Dheeraj
通讯作者：
Gupta, Dheeraj
DOI：
10.1056/nejmra0910061
发表时间：
2010-12-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Fahy JV;Dickey BF
通讯作者：
Dickey BF
DOI：
10.5455/msm.2012.24.100-105
发表时间：
2012
期刊：
Materia socio-medica
影响因子：
--
作者：
Cukic V;Lovre V;Dragisic D;Ustamujic A
通讯作者：
Ustamujic A
影响因子：
4.2
作者：
Feemster KA;Li Y;Localio AR;Shults J;Edelstein P;Lautenbach E;Smith T;Metlay JP
通讯作者：
Metlay JP
影响因子：
5.4
作者：
Avadhanula, V;Rodriguez, CA;Adderson, EE
通讯作者：
Adderson, EE