The Prevalence of Frascati-Criteria-Based HIV-Associated Neurocognitive Disorder (HAND) in HIV-Infected Adults: A Systematic Review and Meta-Analysis.
The Prevalence of Frascati-Criteria-Based HIV-Associated Neurocognitive Disorder (HAND) in HIV-Infected Adults: A Systematic Review and Meta-Analysis.
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HIV 感染成人中基于弗拉斯卡蒂标准的 HIV 相关神经认知障碍 (HAND) 的患病率：系统回顾和荟萃分析
DOI：
10.3389/fneur.2020.581346
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发表时间：
2020
影响因子：
3.4
通讯作者：
Zhang T
中科院分区：
文献类型：
--
作者：
Wei J;Hou J;Su B;Jiang T;Guo C;Wang W;Zhang Y;Chang B;Wu H;Zhang T
背景：由于抗逆转录病毒治疗的广泛使用，大多数国家的艾滋病毒相关死亡率正在下降。然而，艾滋病毒相关的神经认知障碍(HAND)仍然是一个问题，它降低了艾滋病毒携带者的生活质量，增加了公共卫生负担。手部疾病的患病率在不同的研究和选定的样本中有所不同。因此，我们的目标是定量总结基于Frascati标准的手的合并患病率，并探索潜在的人口学、临床和免疫学因素。方法：应用计算机检索PubMed/Medline、Web of Science、Embase、CogcINFO等数据库中的文献。使用事件发生率(ER)进行随机效应荟萃分析，以估计手的发病率。亚组Meta分析用于评估组间分类变量的差异。采用无限制最大似然(ML)法进行Meta回归，评价连续变量间的关联性。结果：共纳入18项研究，样本量在206~1555之间。HAND、ANI、MND和HAD的估计患病率分别为44.9%(95%可信区间37.4~52.7%)、26.2%(95%可信区间20.7~32.7%)、8.5%(95%可信区间5.6~12.7%)、2.1%(95%可信区间1.2~3.7%)。与手相关的因素是女性百分比、目前的CD4计数、教育水平和国家发展水平(均为PS<；0.05)。结论：需要进行纵向队列和多模式神经影像研究，以验证手的临床预后和潜在的神经认知机制。此外，迫切需要建立标准化的手部诊断程序。
Background: The HIV associated mortality is decreasing in most countries due to the widespread use of antiretroviral therapy. However, HIV-associated neurocognitive disorder (HAND) remains a problematic issue that lowers the quality of life and increases the public health burden among people living with HIV. The prevalence of HAND varies across studies and selected samples. Therefore, we aimed to quantitatively summarize the pooled prevalence of Frascati-criteria-based HAND and to explore the potential demographic, clinical, and immunological factors. Methods: A comprehensive literature search in PubMed/Medline, Web of Science, Embase, and PsycINFO was performed. A random-effects meta-analysis was conducted using the event rate (ER) for the estimation of the incidence of HAND. Subgroup meta-analyses were used to evaluate between-group differences in categorical variables. Meta-regression with the unrestricted maximum likelihood (ML) method was used to evaluate associations of continuous variables. Results: Eighteen studies whose sample sizes ranged from 206 to 1555 were included in the final analyses. The estimated prevalence of HAND, ANI, MND and HAD were 44.9% (95% CI 37.4–52.7%), 26.2% (95% CI 20.7–32.7%), 8.5% (95% CI 5.6–12.7%), 2.1% (95% CI 1.2–3.7%), respectively. Factors associated with HAND were percent female, current CD4 count, education level and country development level (all ps < 0.05). Conclusion: Longitudinal cohort and multimodal neuroimaging studies are needed to verify the clinical prognosis and the underlying neurocognitive mechanism of HAND. In addition, it is urgently necessary to establish a standardized HAND diagnostic process.
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影响因子：
4.4
作者：
Haddow LJ;Laverick R;Daskalopoulou M;McDonnell J;Lampe FC;Gilson R;Speakman A;Antinori A;Balestra P;Bruun T;Gerstoft J;Nielsen L;Vassilenko A;Collins S;Rodger AJ;Cognitive Impairment in People with HIV in the European Region (CIPHER) Study Group
通讯作者：
Cognitive Impairment in People with HIV in the European Region (CIPHER) Study Group
影响因子：
4.6
作者：
Kamminga, Jody;Cysique, Lucette A.;Lu, Grace;Batchelor, Jennifer;Brew, Bruce J.
通讯作者：
Brew, Bruce J.
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
9.9
作者：
Grant, Igor;Franklin, Donald R., Jr.;Heaton, Robert K.
通讯作者：
Heaton, Robert K.
影响因子：
11.8
作者：
Antinori, Andrea;Arendt, Gabriele;Munoz-Moreno, Jose A.
通讯作者：
Munoz-Moreno, Jose A.