Multicenter European Prevalence Study of Neurocognitive Impairment and Associated Factors in HIV Positive Patients.
Multicenter European Prevalence Study of Neurocognitive Impairment and Associated Factors in HIV Positive Patients.
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DOI：
10.1007/s10461-017-1683-z
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发表时间：
2018-05
影响因子：
4.4
通讯作者：
Cognitive Impairment in People with HIV in the European Region (CIPHER) Study Group
中科院分区：
文献类型：
--
作者：
Haddow LJ;Laverick R;Daskalopoulou M;McDonnell J;Lampe FC;Gilson R;Speakman A;Antinori A;Balestra P;Bruun T;Gerstoft J;Nielsen L;Vassilenko A;Collins S;Rodger AJ;Cognitive Impairment in People with HIV in the European Region (CIPHER) Study Group
我们进行了一项横断面研究，在448名艾滋病毒阳性患者参加欧洲五个门诊诊所，以确定神经认知功能障碍（NCI）的患病率和相关因素，使用计算机和纸笔神经心理测试。NCI定义为5个认知领域中至少有2个领域的标准化Z评分≤-1。参与者的平均年龄为45.8岁; 84%为男性; 87%为白色; 56%受过大学教育; CD 4计数中位数为550个细胞/mm 3; 89%接受抗逆转录病毒治疗。156名（35%）参与者患有NCI，其中26名（17%;总体5.8%）报告日常生活活动下降。在那些始终能够负担得起基本需求的人群中，（校正的患病率[aPR] 0.71，95%置信区间[CI] 0.54-0.94）或具有大学学历（aPR 0.72，95% CI 0.54-0.97），重度抑郁症状患者更高（aPR 1.53，95% CI 1.09-2.14）或显著共病（aPR 1.40，95% CI 1.03-1.90）。
We conducted a cross-sectional study in 448 HIV positive patients attending five European outpatient clinics to determine prevalence of and factors associated with neurocognitive impairment (NCI) using computerized and pen-and-paper neuropsychological tests. NCI was defined as a normalized Z score ≤−1 in at least 2 out of 5 cognitive domains. Participants’ mean age was 45.8 years; 84% male; 87% white; 56% university educated; median CD4 count 550 cells/mm3; 89% on antiretroviral therapy. 156 (35%) participants had NCI, among whom 26 (17%; 5.8% overall) reported a decline in activities of daily living. Prevalence of NCI was lower in those always able to afford basic needs (adjusted prevalence ratio [aPR] 0.71, 95% confidence interval [CI] 0.54–0.94) or with a university education (aPR 0.72, 95% CI 0.54–0.97) and higher in those with severe depressive symptoms (aPR 1.53, 95% CI 1.09–2.14) or a significant comorbid condition (aPR 1.40, 95% CI 1.03–1.90).
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HIV 相关神经认知障碍中基于表现的功能测量的比较。
影响因子：
3.2
作者：
Gandhi, Nishiena S.;Skolasky, Richard L.;Peters, Katherine B.;Moxley, Richard T.;Creighton, Jason;Roosa, Heidi Vornbrock;Selnes, Ola A.;McArthur, Justin;Sacktor, Ned
通讯作者：
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影响因子：
11.2
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通讯作者：
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影响因子：
4.4
作者：
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通讯作者：
Palha, Antonio
影响因子：
9.9
作者：
Grant, Igor;Franklin, Donald R., Jr.;Heaton, Robert K.
通讯作者：
Heaton, Robert K.
DOI：
10.1017/s1355617703910071
发表时间：
2003-01-01
影响因子：
2.6
作者：
Gonzalez, R;Heaton, RK;Grant, I
通讯作者：
Grant, I