Synthesis of Zn-Cu-In-S/ZnS core/shell quantum dots with inhibited blue-shift photoluminescence and applications for tumor targeted bioimaging.
Synthesis of Zn-Cu-In-S/ZnS core/shell quantum dots with inhibited blue-shift photoluminescence and applications for tumor targeted bioimaging.
复制标题
抑制蓝移光致发光的 Zn-Cu-In-S/ZnS 核/壳量子点的合成及其在肿瘤靶向生物成像中的应用
作者：
Guo W;Chen N;Tu Y;Dong C;Zhang B;Hu C;Chang J
本文报道了一种简单的合成Zn-Cu-In-S/ZnS（ZCIS/ZnS）核壳量子点的方法，以解决CuInS 2基纳米晶的蓝移问题。在该策略中，在ZnS壳涂层之前，有意地采用Zn 2+离子用于合成合金化ZCIS核量子点，这有助于减少光致发光（PL）发射的蓝移。实验结果表明，这种精心设计的简单策略可以有效减少贝壳生长过程中的蓝移。特别地，提出并证明了一个假设来解释这种有效的策略。也就是说，在ZCIS/ZnS量子点的合成过程中，既涉及阳离子交换抑制，又涉及离子积累。此外，所获得的近红外（NIR）ZCIS/ZnS量子点转移到水相的聚合物涂层技术，并与环精氨酸-甘氨酸-天冬氨酸肽（cRGD）肽偶联。在通过对正常3 T3细胞的细胞毒性试验确认生物相容性后，将这些QD通过尾静脉注射到携带U87 MG肿瘤的裸鼠中。结果表明，注射ZCIS/ZnS-cRGD量子点的肿瘤区域中检测到的信号比注射ZCIS/ZnS量子点的肿瘤区域中检测到的信号更有区别。
A facile strategy is reported here for synthesis of Zn-Cu-In-S/ZnS (ZCIS/ZnS) core/shell QDs to address the synthetic issues that the unexpected blue-shift of CuInS2-based nanocrystals. In this strategy, Zn2+ ions are intentionally employed for the synthesis of alloyed ZCIS core QDs before ZnS shell coating, which contributes to the reduced blue-shift in photoluminescence (PL) emission. The experimental results demonstrate this elaborate facile strategy is effective for the reduction of blue-shift during shell growth. Particularly, a hypothesis is proposed and proved for explanation of this effective strategy. Namely, both cation exchange inhibition and ions accumulation are involved during the synthesis of ZCIS/ZnS QDs. Furthermore, the obtained near infrared (NIR) ZCIS/ZnS QDs are transferred into aqueous phase by a polymer coating technique and coupled with cyclic Arg-Gly-Asp peptide (cRGD) peptides. After confirmation of biocompability by cytotoxicity test on normal 3T3 cells, these QDs are injected via tail vein into nude mice bearing U87 MG tumor. The result indicates that the signals detected in the tumor region are much more distinguishing injected with ZCIS/ZnS-cRGD QDs than that injected with ZCIS/ZnS QDs.
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