Comparing BMI with skinfolds to estimate age at adiposity rebound and its associations with cardio-metabolic risk markers in adolescence.
Comparing BMI with skinfolds to estimate age at adiposity rebound and its associations with cardio-metabolic risk markers in adolescence.
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DOI：
10.1038/s41366-018-0144-8
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发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
Fall CHD
中科院分区：
文献类型：
--
作者：
Di Gravio C;Krishnaveni GV;Somashekara R;Veena SR;Kumaran K;Krishna M;Karat SC;Fall CHD
体重指数（BMI）在儿童中期达到最低点，称为肥胖反弹（AR）。早期AR与晚年患心血管疾病的风险较高相关。皮褶厚度是一种更直接的肥胖测量方法，可以更好地了解儿童肥胖与后来肥胖和心脏代谢风险之间的关系。我们的目的是评估AR是否对应于皮褶的反弹，并比较BMI衍生的AR和皮褶衍生的AR与青春期心脏代谢风险标志物的相关性。我们使用惩罚样条与随机系数，估计体重指数和皮肤褶皱轨迹的604名儿童从迈索尔帕台农出生队列。AR时的年龄通过区分BMI和2至10岁之间的皮褶生长曲线来确定。在13.5岁时，我们测量了血压、葡萄糖、胰岛素和脂质浓度。BMI和皮褶厚度有不同的增长模式。男孩比皮褶来源的AR更早达到BMI来源的AR（估计差异：0.41年; 95% CI：[0.23，0.56]），而女孩则相反（估计差异：-0.71年; 95% CI：[-0.90，-0.54]）。在13.5岁时，早期BMI衍生AR的儿童具有较高的BMI（AR每增加一个标准差，即增加-0.58标准差; 95%CI：[-0.65，-0.52]）、脂肪量（-0.44; 95%CI：[-0.50，-0.37]）、胰岛素抵抗（HOMA-IR：-0.20; 95%CI：[-0.28，-0.12]）和收缩压（-0.20; 95%CI：[-0.28，-0.11]），以及较低的HDL-胆固醇（0.12; 95%CI：[0.04，0.21]）。这些关联在反弹时与BMI无关，但在13.5岁时完全由脂肪量解释。皮褶来源的AR也发现了类似的相关性。BMI衍生的肥胖反弹预测随后的心脏代谢风险标志物，类似于来自皮肤褶皱，肥胖的直接测量。
Body mass index (BMI) reaches a nadir in mid-childhood, known as the adiposity rebound (AR). Earlier AR is associated with a higher risk of cardio-vascular diseases in later life. Skinfolds, which are a more direct measure of adiposity, may give better insight into the relationship between childhood adiposity and later obesity and cardio-metabolic risk. We aimed to assess whether AR corresponds to a rebound in skinfolds, and compare associations of BMI-derived AR and skinfold-derived AR with cardio-metabolic risk markers in adolescence. We used penalised splines with random coefficients to estimate BMI and skinfold trajectories of 604 children from the Mysore Parthenon Birth Cohort. Age at AR was identified using differentiation of the BMI and skinfold growth curves between 2 and 10 years of age. At 13.5 years, we measured blood pressure, and glucose, insulin and lipid concentrations. BMI and skinfolds had different growth patterns. Boys reached BMI-derived AR earlier than skinfold-derived AR (estimated difference: 0.41 years; 95% CI:[0.23, 0.56]), whereas the opposite was observed in girls (estimated difference: −0.71 years; 95% CI:[−0.90, −0.54]). At 13.5 years, children with earlier BMI-derived AR had higher BMI (−0.58 SD per SD increase of AR; 95%CI:[−0.65, −0.52]), fat mass (−0.44; 95%CI:[−0.50, −0.37]), insulin resistance (HOMA-IR: −0.20; 95%CI:[−0.28, −0.12]) and systolic blood pressure (−0.20; 95%CI:[−0.28, −0.11]), and lower HDL-cholesterol (0.12; 95%CI:[0.04, 0.21]). The associations were independent of BMI at time of rebound, but were fully explained by fat mass at 13.5 years. Similar associations were found for skinfold-derived AR. BMI-derived adiposity rebound predicts later cardio-metabolic risk markers similarly to that derived from skinfolds, a direct measure of adiposity.
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影响因子：
--
作者：
Campbell, Michele Wen-Chien;Williams, Joanne;Wake, Melissa
通讯作者：
Wake, Melissa
影响因子：
168.9
作者：
Adair, Linda S.;Fall, Caroline H. D.;Osmond, Clive;Stein, Aryeh D.;Martorell, Reynaldo;Ramirez-Zea, Manuel;Sachdev, Harshpal Singh;Dahly, Darren L.;Bas, Isabelita;Norris, Shane A.;Micklesfield, Lisa;Hallal, Pedro;Victora, Cesar G.
通讯作者：
Victora, Cesar G.
影响因子：
2
作者：
COLE, TJ;GREEN, PJ
通讯作者：
GREEN, PJ
影响因子：
4.7
作者：
Plachta-Danielzik, S.;Bosy-Westphal, A.;Mueller, M. J.
通讯作者：
Mueller, M. J.
影响因子：
4.7
作者：
Kehoe, S. H.;Krishnaveni, G. V.;Kurpad, A.
通讯作者：
Kurpad, A.