Diverse roles for T-bet in the effector responses required for resistance to infection.
Diverse roles for T-bet in the effector responses required for resistance to infection.
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DOI：
10.4049/jimmunol.1401617
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发表时间：
2015-02-01
期刊：
影响因子：
--
通讯作者：
Hunter CA
中科院分区：
文献类型：
--
作者：
Harms Pritchard G;Hall AO;Christian DA;Wagage S;Fang Q;Muallem G;John B;Glatman Zaretsky A;Dunn WG;Perrigoue J;Reiner SL;Hunter CA
转录因子T-bet与自然杀伤细胞(NK)和T细胞产生干扰素-γ(干扰素-γ)密切相关，干扰素-DNA是控制多种细胞内病原体所需的一种细胞因子。事实上，在受到弓形虫寄生虫攻击的小鼠中，NK和T细胞反应的特征是T-bet表达显著增加。出乎意料的是，感染弓形虫的T-bet−/−小鼠产生了强烈的NK细胞干扰素-γ反应，控制了挑战部位的寄生虫复制，但在弓形虫定植的次级部位表现出高寄生虫负担并死于感染。T-bet的缺失对干扰素-γ的T细胞产生影响不大，但对寄生虫特异性T细胞的产生没有影响。然而，T-bet的缺失导致CD11a、Ly6C、KLRG-1和CXCR3的T细胞表达降低，继发感染部位的寄生虫特异性T细胞减少，与这些部位的寄生虫控制缺陷有关。总之，这些数据强调了T-BET独立的干扰素-γ产生途径，并揭示了这种转录因子在协调控制外周组织感染所需的T细胞反应中的新作用。
The transcription factor T-bet has been most prominently linked to natural killer (NK) and T cell production of interferon-γ (IFN-γ), a cytokine required for the control of a diverse array of intracellular pathogens. Indeed, in mice challenged with the parasite Toxoplasma gondii, NK and T cell responses are characterized by marked increases of T-bet expression. Unexpectedly, T-bet−/− mice infected with T. gondii develop a strong NK cell IFN-γ response that controls parasite replication at the challenge site, but display high parasite burdens at secondary sites colonized by T. gondii and succumb to infection. The loss of T-bet had a modest effect on T cell production of IFN-γ but did not impact on the generation of parasite-specific T cells. However, the absence of T-bet resulted in lower T cell expression of CD11a, Ly6C, KLRG-1, and CXCR3 and fewer parasite-specific T cells at secondary sites of infection, associated with a defect in parasite control at these sites. Together, these data highlight T-bet independent pathways to IFN-γ production, and reveal a novel role for this transcription factor in coordinating the T cell responses necessary to control this infection in peripheral tissues.
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影响因子：
64.8
作者：
Harris, Tajie H.;Banigan, Edward J.;Christian, David A.;Konradt, Christoph;Wojno, Elia D. Tait;Norose, Kazumi;Wilson, Emma H.;John, Beena;Weninger, Wolfgang;Luster, Andrew D.;Liu, Andrea J.;Hunter, Christopher A.
通讯作者：
Hunter, Christopher A.
影响因子：
5.4
作者：
Fadell, Shaza A.;Bromley, Shannon K.;Medoff, Benjamin D.;Luster, Andrew D.
通讯作者：
Luster, Andrew D.
影响因子：
30.5
作者：
Intlekofer, AM;Takemoto, N;Reiner, SL
通讯作者：
Reiner, SL
在不受欢迎的记忆CD8+ T细胞的异常分化中T-BET的需求。
DOI：
10.1084/jem.20070841
发表时间：
2007-09-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Intlekofer AM;Takemoto N;Kao C;Banerjee A;Schambach F;Northrop JK;Shen H;Wherry EJ;Reiner SL
通讯作者：
Reiner SL
影响因子：
15.3
作者：
Juedes, AE;Rodrigo, E;Togher, L;Glimcher, LH;von Herrath, MG
通讯作者：
von Herrath, MG