A prefrontal cortex alpha/delta switch controls the transition from positive to negative affective states.
A prefrontal cortex alpha/delta switch controls the transition from positive to negative affective states.
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前额叶皮层α/delta开关控制从正面情感状态到负面状态的过渡。
DOI：
10.1007/s44192-023-00044-3
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发表时间：
2023-10-10
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影响因子：
--
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大鼠的积极和消极情绪状态可以通过研究超声波发声（USVs）来研究。大鼠中的积极影响由50 kHz的享乐USVs索引，消极影响由22 kHz的厌恶呼叫索引。我们使用内侧前额叶皮层（MPFC）定量脑电图（qEEG）研究了大鼠情绪状态的关系，发现快乐USV与活跃唤醒qEEG（高α/低δ功率）相关，而厌恶USV与昏昏沉沉的唤醒qEEG（低α/高δ功率）相关。此外，MPFC的α频率电刺激诱导享乐呼叫和奖励寻求行为，而δ频率刺激产生厌恶呼叫和回避行为。负责为USV产生运动输出的大脑区域，即导水管周围灰质（PAG），显示出运动诱发电位，其在时间上锁定于α（享乐）和δ（厌恶）运动诱发电位。闭环α频率电刺激可以防止delta qEEG和厌恶性USV。在神经元回路水平，α节律与皮层中的突触长时程增强（LTP）相关，而δ节律与皮层中的突触去增强（LTD）相关。在药理学水平上，NMDAR和生长因子调节这些形式的神经可塑性。在单个神经元水平上，兴奋性神经元响应于α频率显示出增加的活性，并且在δ频率期间显示出减少的活性。在人类中，快乐的感觉增加了前额头皮qEEG的α功率，降低了δ功率，而悲伤的反应则相反。因此，通过负责情绪表达的神经元回路的α/δ振荡的同步化协调情绪行为，并且在活跃的唤醒/积极的情感和昏昏沉沉的唤醒/消极的情感之间的切换是在LTP- LTD突触可塑性机制的控制下。
Positive and negative emotional states in rats can be studied by investigating ultrasonic vocalizations (USVs). Positive affect in rats is indexed by 50 kHz hedonic USVs, and negative affect is indexed by 22 kHz aversive calls. We examined the relationship of emotional states in rats using medial prefrontal cortex (MPFC) quantitative electroencephalograms (qEEG) and found that hedonic USVs were associated with active wake qEEG (high alpha/low delta power), and aversive USVs occurred with groggy wake qEEG (low alpha/high delta). Further, alpha frequency electrical stimulation of the MPFC induces hedonic calls and reward-seeking behavior, whereas delta frequency stimulation produces aversive calls and avoidance behavior. The brain region responsible for generating motor output for USVs, the periaqueductal gray (PAG), shows a motor-evoked potential that is temporally locked to the alpha (hedonic) and delta (aversive) motor-evoked potential. Closed-loop alpha frequency electrical stimulation could prevent delta qEEG and aversive USVs. At the neuronal circuit level, the alpha rhythm was associated with synaptic long-term potentiation (LTP) in the cortex, whereas the delta rhythm was associated with synaptic depotentiation (LTD) in the cortex. At the pharmacological level, NMDAR and growth factor modulation regulated these forms of neuroplasticity. At the single neuron level, excitatory neurons show increased activity in response to alpha frequencies and decreased activity during delta frequencies. In humans, the feeling of joy increased alpha and decreased delta power in frontal scalp qEEG, and the opposite response was seen for sadness. Thus, the synchronization of alpha/delta oscillations through the neuronal circuit responsible for emotional expression coordinates emotional behavior, and the switch between active wake/positive affect and groggy wake/negative affect is under the control of an LTP- LTD synaptic plasticity mechanism.
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影响因子：
64.8
作者：
Wang Z;Ma J;Miyoshi C;Li Y;Sato M;Ogawa Y;Lou T;Ma C;Gao X;Lee C;Fujiyama T;Yang X;Zhou S;Hotta-Hirashima N;Klewe-Nebenius D;Ikkyu A;Kakizaki M;Kanno S;Cao L;Takahashi S;Peng J;Yu Y;Funato H;Yanagisawa M;Liu Q
通讯作者：
Liu Q
影响因子：
3.3
作者：
Vera, Jorge;Pereira, Ulises;Sanhueza, Magdalena
通讯作者：
Sanhueza, Magdalena
影响因子：
16.2
作者：
Tononi G;Cirelli C
通讯作者：
Cirelli C
影响因子：
11
作者：
Burgdorf, Jeffrey S.;Yoon, Sehyoun;Dos Santos, Marc;Lammert, Catherine R.;Moskal, Joseph R.;Penzes, Peter
通讯作者：
Penzes, Peter
影响因子：
3.4
作者：
Burgdorf, Jeffrey S.;Christian, E. P.;Moskal, J. R.
通讯作者：
Moskal, J. R.