Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration.
Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration.
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DOI：
10.1016/j.neuron.2013.12.025
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发表时间：
2014-01-08
期刊：
影响因子：
16.2
通讯作者：
Cirelli C
中科院分区：
文献类型：
--
作者：
Tononi G;Cirelli C
睡眠是普遍存在的，受到严格控制，睡眠的丧失会损害认知能力。但为什么大脑每天需要与环境断开几个小时呢？突触稳态假说（SHY）提出，睡眠是大脑为可塑性付出的代价。在清醒状态下，了解当前环境的统计规律需要加强整个大脑的连接。这增加了细胞对能量和供应的需求，降低了信噪比，并使学习饱和。在睡眠期间，自发活动使净突触强度重新正常化并恢复细胞稳态。突触的活动依赖性下调也可以解释睡眠对记忆获取、巩固和整合的好处。这是通过对一生中神经元回路中的统计规律进行离线、全面的采样来实现的。这篇综述考虑了 SHY 的基本原理和证据，并指出了与睡眠和可塑性相关的开放性问题。
Sleep is universal, tightly regulated, and its loss impairs cognition. But why does the brain need to disconnect from the environment for hours every day? The synaptic homeostasis hypothesis (SHY) proposes that sleep is the price the brain pays for plasticity. During a waking episode, learning statistical regularities about the current environment requires strengthening connections throughout the brain. This increases cellular needs for energy and supplies, decreases signal-to-noise ratios, and saturates learning. During sleep, spontaneous activity renormalizes net synaptic strength and restores cellular homeostasis. Activity-dependent down-selection of synapses can also explain the benefits of sleep on memory acquisition, consolidation, and integration. This happens through the off-line, comprehensive sampling of statistical regularities incorporated in neuronal circuits over a lifetime. This review considers the rationale and evidence for SHY and points to open issues related to sleep and plasticity.
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DOI：
10.1126/science.1202839
发表时间：
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期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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发表时间：
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影响因子：
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