Effects of information processing speed on learning, memory, and executive functioning in people living with HIV/AIDS.
Effects of information processing speed on learning, memory, and executive functioning in people living with HIV/AIDS.
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DOI：
10.1080/13803395.2014.943696
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发表时间：
2014
影响因子：
2.2
通讯作者：
Morgello S
中科院分区：
文献类型：
--
作者：
Fellows RP;Byrd DA;Morgello S
目前尚不清楚在联合抗逆转录病毒治疗（CART）时代，识字、衰老和其他神经异常是否或在多大程度上与艾滋病毒/艾滋病感染者的认知缺陷有关。本研究的主要目的是同时检查年龄、HIV相关运动异常、重度抑郁症和阅读水平与信息处理速度、学习、记忆和执行功能的关系，并确定处理速度是否介导认知和非认知变量之间的任何关系。参与者是186名不同种族和民族的艾滋病毒/艾滋病感染者，他们接受了全面的神经学，神经心理学和医学评估。结构方程模型被用来评估在何种程度上信息处理速度介导的年龄，运动异常，抑郁症，阅读水平与其他认知能力之间的关系。年龄、运动功能障碍、阅读水平和当前的重性抑郁障碍都与信息处理速度显著相关。信息处理速度完全介导年龄对学习、记忆和执行功能的影响，部分介导抑郁症对学习和记忆的影响。运动功能障碍对学习记忆的影响完全由加工速度介导。这些研究结果提供了支持信息处理速度作为一个主要的缺陷，这可能占，至少部分地，为许多其他认知异常复杂的艾滋病毒/艾滋病人群。年龄和信息处理速度的相关性可能是艾滋病毒/衰老协同作用产生CART时代认知异常的原因。
It is unclear whether or to what degree literacy, aging, and other neurologic abnormalities relate to cognitive deficits among people living with HIV/AIDS in the combined antiretroviral therapy (CART) era. The primary aim of this study was to simultaneously examine the association of age, HIV-associated motor abnormalities, major depressive disorder, and reading level with information processing speed, learning, memory, and executive functions, and to determine if processing speed mediated any of the relationships between cognitive and non-cognitive variables. Participants were 186 racially and ethnically diverse men and women living with HIV/AIDS who underwent comprehensive neurological, neuropsychological, and medical evaluations. Structural equation modeling was utilized to assess the extent to which information processing speed mediated the relationship between age, motor abnormalities, major depressive disorder, and reading level with other cognitive abilities. Age, motor dysfunction, reading level, and current major depressive disorder were all significantly associated with information processing speed. Information processing speed fully mediated the effects of age on learning, memory, and executive functioning, and partially mediated the effect of major depressive disorder on learning and memory. The effect of motor dysfunction on learning and memory was fully mediated by processing speed. These findings provide support for information processing speed as a primary deficit which may account, at least in part, for many of the other cognitive abnormalities recognized in complex HIV/AIDS populations. The association of age and information processing speed may account for HIV/aging synergies in the generation of CART-era cognitive abnormalities.
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DOI：
10.1080/13803390802375557
发表时间：
2009-07-01
影响因子：
2.2
作者：
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发表时间：
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