WISP1 polymorphisms contribute to platinum-based chemotherapy toxicity in lung cancer patients.
WISP1 polymorphisms contribute to platinum-based chemotherapy toxicity in lung cancer patients.
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WISP1 多态性导致肺癌患者铂类化疗出现毒性。
DOI：
10.3390/ijms151121011
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发表时间：
2014-11-14
影响因子：
5.6
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Chen J;Yin J;Li X;Wang Y;Zheng Y;Qian C;Xiao L;Zou T;Wang Z;Liu J;Zhang W;Zhou H;Liu Z
铂类化疗毒性一直是困扰肺癌患者的严重问题之一。在我们以前的研究中发现WISP1的基因多态与易感性和铂类药物的化疗反应有关。本研究旨在探讨肺癌患者中WISP1基因多态性与铂类药物化疗毒性的关系。本研究共纳入412例肺癌患者，应用SequenomMassarray对WISP1基因28个多态性进行了基因分型。亚组分析发现，WISP1基因(rs2929965、rs2929969、rs2929970、rs2929973和rs754958)与肺癌的总体化疗毒性相关。Rs16904853、rs2929970、rs2977549和rs2977551(p分别为0.021、0.028、0.024、0.048)与血液毒性显著相关。Rs2929946、rs2929970、rs2977519、rs2977536、rs3739262和rs754958基因多态性(分别为0.031、0.046、0.029、0.016、0.042、0.035)与肺癌的胃肠道毒性显著相关。WISP1基因分型可能成为预测肺癌患者铂类化疗毒性的新的有用的生物标志物。
Platinum-based chemotherapy toxicity is always one of the serious problems from which lung cancer patients suffer. The genetic polymorphism of WISP1 was revealed to be associated with susceptibility and platinum-based chemotherapy response in our previous studies. In this study, we aimed to investigate the relationship of WISP1 genetic polymorphisms with platinum-based chemotherapy toxicity in lung cancer patients. A total of 412 lung cancer patients were enrolled in this study, and 28 polymorphisms of the WISP1 gene were genotyped by SequenomMassARRAY. We found that WISP1 polymorphisms (rs2929965, rs2929969, rs2929970, rs2929973 and rs754958) were related to the overall chemotherapy toxicity of lung cancer in subgroup analyses. Rs16904853, rs2929970, rs2977549 and rs2977551 (p = 0.021, 0.028, 0.024, 0.048, respectively) polymorphisms were significantly associated with hematologic toxicity. Rs2929946, rs2929970, rs2977519, rs2977536, rs3739262 and rs754958 (p = 0.031, 0.046, 0.029, 0.016, 0.042, 0.035, respectively) polymorphisms were significantly associated with the gastrointestinal toxicity of lung cancer. Genotypes of WISP1 may be novel and useful biomarkers for predicting platinum-based chemotherapy toxicity in lung cancer patients.
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影响因子：
4.7
作者：
Watari, Hidemichi;Xiong, Ying;Sakuragi, Noriaki
通讯作者：
Sakuragi, Noriaki
影响因子：
9.7
作者：
Lee, Kwang Bok;Ye, Shuai;Kim, Soo Mi
通讯作者：
Kim, Soo Mi
影响因子：
9
作者：
通讯作者：
--
DOI：
10.1073/pnas.95.25.14717
发表时间：
1998-12-08
影响因子：
11.1
作者：
Pennica, D;Swanson, TA;Levine, AJ
通讯作者：
Levine, AJ
影响因子：
10.5
作者：
Lien WH;Fuchs E
通讯作者：
Fuchs E