Specialized proteasome subunits play an essential role in thymic selection of CD8+ T cells
Specialized proteasome subunits play an essential role in thymic selection of CD8+ T cells
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特殊的蛋白酶体亚基在 CD8 T 细胞的胸腺选择中发挥重要作用
作者：
Eleanor Z. Kincaid;S. Murata;Keiji Tanaka;K. Rock
刺激正选择的细胞表达与所有其他细胞（包括参与负选择的细胞）表达的蛋白酶体β亚基不同的特化蛋白酶体β亚基。缺乏所有四种特化蛋白酶体β亚基的小鼠，因此在所有细胞中仅表达组成型蛋白酶体，在CD8+ T细胞的产生方面存在严重缺陷。虽然正选择中的缺陷将反映不能产生适当的正选择肽，但负选择的阻断将指出潜在需要在正选择和负选择之间切换肽以避免两个过程经常相互抵消。我们发现，T细胞发育的阻滞发生在阳性选择的检查点周围，出乎意料的是，阴性选择也是如此。
The cells that stimulate positive selection express specialized proteasome β-subunits different from those expressed by all other cells, including those involved in negative selection. Mice that lack all four specialized proteasome β-subunits, and therefore express only constitutive proteasomes in all cells, had a profound defect in the generation of CD8+ T cells. While a defect in positive selection would reflect an inability to generate the appropriate positively selecting peptides, a block at negative selection would point to the potential need to switch peptides between positive selection and negative selection to avoid the two processes' often cancelling each other out. We found that the block in T cell development occurred around the checkpoints of positive selection and, unexpectedly, negative selection as well.
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影响因子：
32.4
作者：
Gray DH;Kupresanin F;Berzins SP;Herold MJ;O'Reilly LA;Bouillet P;Strasser A
通讯作者：
Strasser A
DOI：
10.1038/nri3667
发表时间：
2014-06
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Klein L;Kyewski B;Allen PM;Hogquist KA
通讯作者：
Hogquist KA
影响因子：
16
作者：
Kisselev, AF;Akopian, TN;Goldberg, AL
通讯作者：
Goldberg, AL
共刺激分子 B7 在小鼠胸腺的髓质区域表达。
影响因子：
6.4
作者：
Reiser,H;Schneeberger,EE
通讯作者：
Schneeberger,EE
影响因子：
56.9
作者：
MARRACK, P;KAPPLER, J
通讯作者：
KAPPLER, J