Localization of COX-1 and COX-2 in the intracranial dura mater of the rat.
Localization of COX-1 and COX-2 in the intracranial dura mater of the rat.
复制标题
DOI：
10.1016/j.neulet.2009.01.032
复制
发表时间：
2009-03-06
影响因子：
2.5
通讯作者：
Levy D
中科院分区：
文献类型：
--
作者：
Zhang XC;Kainz V;Jakubowski M;Burstein R;Strassman A;Levy D
Primary headaches such as migraine can be aborted by systemic administration of non-steroidal anti-inflammatory drugs (NSAIDs), potentially through the non-selective inhibition of cyclooxygenase (COX) activity in the intracranial meninges. In this study we have used single and double labeling immunohistochemistry to examine the distribution of the COX-1 and COX-2 isoforms in the intracranial dura mater of the rat and identify cell types that express them. COX-1 immunoreactivity was found in medium and small dural blood vessels and was co-expressed with the endothelial cell markers vimentin and the endothelial isoform of nitric oxide synthase (ecNOS). COX-1 was also found to be present in most dural mast cells. COX-2 was mainly expressed in ED2-positive resident dural macrophages. Constitutive COX-2 expression was also found in some axonal profiles, many of which were co-labeled with the nociceptor peptide marker CGRP. The findings suggest that NSAIDs may abort headache, at least in part, by inhibiting either neuronal or non-neuronal COX activity in the dura mater.
登录
查看更多内容
影响因子：
3.4
作者：
Chopra, B;Giblett, S;Grubb, BD
通讯作者：
Grubb, BD
影响因子：
4.9
作者：
Prior, MJ;Cooper, KM;Bowen, DL
通讯作者：
Bowen, DL
DOI：
10.1002/neu.10220
发表时间：
2003-08-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
Khalil, MH;Silverman, AJ;Silver, R
通讯作者：
Silver, R
影响因子：
5
作者：
Smith, TR;Sunshine, A;Alexander, WJ
通讯作者：
Alexander, WJ
影响因子：
2.5
作者：
NEMADE, RV;LEWIS, AI;KELLER, JT
通讯作者：
KELLER, JT