Diabetic severity and risk of kidney stone disease.
Diabetic severity and risk of kidney stone disease.
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DOI：
10.1016/j.eururo.2013.03.026
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发表时间：
2014-01
期刊：
影响因子：
23.4
通讯作者：
Leppert, John T.
中科院分区：
文献类型：
--
作者：
Weinberg, Aviva E.;Patel, Chirag J.;Chertow, Glenn M.;Leppert, John T.
随着肥胖、2型糖尿病（T2 DM）和代谢综合征发病率的增加，肾结石疾病的患病率也在沿着上升。探讨2型糖尿病的发生、严重程度、血糖控制和胰岛素抵抗与肾结石的关系。我们对2007-2010年国家健康和营养检查调查（NHANES）中的所有成年参与者进行了横断面分析。通过自我报告获得肾结石病史。T2 DM定义为：自我报告的病史、T2 DM相关药物使用和报告的糖尿病合并症。采用空腹血浆胰岛素（FPI）水平和胰岛素抵抗的稳态模型评估（HOMA-IR）定义来估计胰岛素抵抗。我们使用HbA 1c和空腹血糖水平（FPG）对血糖控制进行分类。计算每个T2 DM严重程度个体指标的肾结石疾病的比值比（OR）。拟合Logistic回归模型，调整年龄、性别、人种/种族、吸烟史和Quételet（体重）指数（BMI）（模型A）以及实验室值和代谢综合征组分（模型B）。肾结石疾病的相关因素包括自我报告的T2 DM病史（OR 2.44，95%置信区间[CI] 1.84-3.25）和胰岛素使用史（OR 3.31，CI 2.02-5.45）。FPG 100-126和>126 mg/dL的人患肾结石的几率增加，OR分别为1.28（CI 0.95-1.72）和2.29（CI 1.68-3.12）。HgbA 1c 5.7-6.4%和≥6.5%人群的相应结果分别为OR 1.68（CI 1.17-2.42）和OR 2.82（CI 1.98-4.02）。当调整患者因素时，T2 DM病史、胰岛素使用、FPI和HgbA 1c仍与肾结石疾病显著相关。横截面设计限制了因果推理。在T2 DM患者中，更严重的疾病与肾结石风险增加相关。
The prevalence of kidney stone disease is rising along with increasing rates of obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome. To investigate the associations among the presence and severity of T2DM, glycemic control and insulin resistance with kidney stone disease. We performed a cross-sectional analysis of all adult participants in the 2007–2010 National Health and Nutrition Examination Survey (NHANES). A history of kidney stone disease was obtained by self-report. T2DM was defined by: self-reported history, T2DM-related medication usage, and reported diabetic comorbidity. Insulin resistance was estimated using fasting plasma insulin (FPI) levels and the homeostasis model assessment of insulin resistance (HOMA-IR) definition. We classified glycemic control using HbA1c and fasting plasma glucose levels (FPG). Odds ratios (OR) for kidney stone disease were calculated for each individual measure of T2DM severity. Logistic regression models were fitted adjusting for age, sex, race/ethnicity, smoking history, and Quételet’s (body mass) index (BMI) (model A) as well as laboratory values and components of metabolic syndrome (model B). Correlates of kidney stone disease included a self-reported history of T2DM (OR 2.44, 95% confidence interval [CI] 1.84–3.25) and history of insulin use (OR 3.31, CI 2.02-5.45). Persons with FPG 100–126 and >126 mg/dL had increased odds of kidney stone disease, OR 1.28 (CI 0.95–1.72) and OR 2.29 (CI 1.68-3.12), respectively. Corresponding results for persons with HgbA1c 5.7-6.4% and ≥6.5% were ORs 1.68 (CI 1.17–2.42) and OR 2.82 (CI 1.98–4.02), respectively. When adjusting for patient factors, a history of T2DM, the use of insulin, FPI and HgbA1c remained significantly associated with kidney stone disease. The cross-sectional design limits causal inference. Among persons with T2DM, more severe disease is associated with a heightened risk of kidney stones.
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影响因子：
120.7
作者：
de Boer, Ian H.;Rue, Tessa C.;Hall, Yoshio N.;Heagerty, Patrick J.;Weiss, Noel S.;Himmelfarb, Jonathan
通讯作者：
Himmelfarb, Jonathan
影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
DOI：
10.1097/01.asn.0000146012.44570.20
发表时间：
2004-12-01
影响因子：
13.6
作者：
Taylor, EN;Stampfer, MJ;Curhan, GC
通讯作者：
Curhan, GC
影响因子：
3.5
作者：
THALASSINOS, NC;HADJIYANNI, P;PHILOKIPROU, D
通讯作者：
PHILOKIPROU, D
影响因子：
1.2
作者：
Kabeya, Yusuke;Kato, Kiyoe;Atsumi, Yoshihito
通讯作者：
Atsumi, Yoshihito