β-Arrestins 1 and 2 are critical regulators of inflammation.
β-Arrestins 1 and 2 are critical regulators of inflammation.
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β-抑制蛋白 1 和 2 是炎症的关键调节因子。
DOI：
10.1177/1753425913501098
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发表时间：
2014-07
期刊：
影响因子：
3.2
通讯作者：
Fan H
中科院分区：
文献类型：
--
作者：
Fan H
β-Arrestins 1 and 2 couple to seven trans-membrane receptors and regulate G protein-dependent signaling, receptor endocytosis and ubiquitylation. Recent studies have uncovered several unanticipated functions of β-arrestins, suggesting that the role of β-arrestins in cell signaling is much broader than originally thought.It is now recognized that β-arrestins can transduce receptor signaling independent of G proteins. The expression of β-arrestins is differentially regulated in immune cells and tissues in response to specific inflammatory stimuli, and β-arrestins are critical regulators of the inflammatory response. This review will focus on β-arrestins in immune cells and the impact of altered expression on the pathogenesis of specific inflammatory diseases. Understanding the role of β-arrestins in inflammation may lead to new strategies to treat inflammatory diseases, such as sepsis, rheumatoid arthritis, asthma, multiple sclerosis, inflammatory bowel disease and atherosclerosis.
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影响因子：
9.1
作者：
Forooghian, Farzin;Cheung, Roy K.;Dosch, Hans-Michael
通讯作者：
Dosch, Hans-Michael
影响因子：
2.2
作者：
Ikeda, Y;Sudoh, A;Ohguro, H
通讯作者：
Ohguro, H
影响因子：
64.8
作者：
Goodman, OB;Krupnick, JG;Benovic, JL
通讯作者：
Benovic, JL
DOI：
10.1165/rcmb.2009-0198oc
发表时间：
2010-09-01
影响因子：
6.4
作者：
Hollingsworth, John W.;Theriot, Barbara S.;Walker, Julia K. L.
通讯作者：
Walker, Julia K. L.
DOI：
10.1186/1364-8535-16-r32
发表时间：
2012-02-22
期刊：
Critical care (London, England)
影响因子：
--
作者：
Bitto A;Minutoli L;David A;Irrera N;Rinaldi M;Venuti FS;Squadrito F;Altavilla D
通讯作者：
Altavilla D