Psychological and Behavioural Effects of Endogenous Testosterone and Anabolic-Androgenic Steroids

Psychological and Behavioural Effects of Endogenous Testosterone and Anabolic-Androgenic Steroids
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内源性睾酮和合成代谢雄激素类固醇的心理和行为影响

DOI:
--
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发表时间:
1996
期刊:
影响因子:
9.8
通讯作者:
James E. Wright
James E. Wright
中科院分区:
医学1区
文献类型:
--
作者:
M. Bahrke;C. Yesalis;James E. Wright

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摘要内源性睾酮水平与动物和人类的攻击行为有关。用于避孕和临床目的的中等剂量外源睾酮的研究表明,对男性性行为和攻击行为基本上没有不利影响。然而,对运动员的调查和病例报告(通常涉及较高剂量)表明,合成代谢雄激素类固醇的使用与情感和精神病综合征以及心理依赖之间存在关联。研究合成代谢雄激素类固醇的心理和行为影响的努力因各种方法学限制而变得复杂。仅报告了 3 项前瞻性、双盲研究,证明使用合成代谢雄激素类固醇导致攻击性或不良公开行为。据估计,美国过去或现在有超过 100 万使用者,使用合成代谢雄激素类固醇的个人中,只有极少数似乎经历了严重到足以导致临床治疗和医疗病例报告的精神障碍。即使在那些受到如此影响的人中,既往精神病史、对成瘾或精神障碍的遗传易感性、环境和同伴影响以及个人期望的作用仍不清楚。
SummaryEndogenous testosterone levels have been linked to aggressive behaviour in both animals and humans. Studies administering moderate doses of exogenous testosterone for contraceptive and clinical purposes reveal essentially no adverse effects on male sexual and aggressive behaviour. However, investigations and case reports of athletes, usually involving higher doses, demonstrate an association between anabolic-androgenic steroid use and affective and psychotic syndromes and psychological dependence. Efforts to study the psychological and behavioural effects of anabolic-androgenic steroids are complicated by a variety of methodological limitations. Only 3 prospective, blinded studies demonstrating aggression or adverse overt behaviour resulting from anabolic-androgenic steroid use have been reported. With estimates of over 1 million past or current users in the US, an extremely small percentage of individuals using anabolic-androgenic steroids appear to experience mental disturbances severe enough to result in clinical treatment and medical case reports. Even among those so affected, the roles of previous psychiatric history, genetic susceptibility to addictions or mental disorders, environmental and peer influences, and individual expectations remain unclear.
高剂量外源睾酮对健康男性的代谢和行为影响。
DOI: 10.1210/jcem.79.2.8045977
发表时间: 1994
期刊: The Journal of clinical endocrinology and metabolism
影响因子: --
作者:
Bagatell,CJ;Heiman,JR;Matsumoto,AM;Rivier,JE;Bremner,WJ
通讯作者: Bremner,WJ
评估合成代谢雄激素类固醇使用者和非使用者的注意力偏差和情绪。
DOI: 10.1016/0376-8716(94)01071-r
发表时间: 1995
影响因子: 4.2
作者:
Bond,AJ;Choi,PY;PopeJr,HG
通讯作者: PopeJr,HG
合成代谢雄激素类固醇依赖性的症状和相关性。
DOI: 10.1111/j.1360-0443.1991.tb03101.x
发表时间: 1991
期刊: British journal of addiction
影响因子: --
作者:
Brower,KJ;Blow,FC;Young,JP;Hill,EM
通讯作者: Hill,EM
合成代谢雄激素类固醇:对社会行为和基线心率的影响。
DOI: 10.1037//0278-6133.9.6.774
发表时间: 1990
期刊: Health psychology : official journal of the Division of Health Psychology, American Psychological Association
影响因子: --
作者:
Rejeski,WJ;Gregg,E;Kaplan,JR;Manuck,SB
通讯作者: Manuck,SB