Discrete coding of stimulus value, reward expectation, and reward prediction error in the dorsal striatum.

Discrete coding of stimulus value, reward expectation, and reward prediction error in the dorsal striatum.
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背侧纹状体刺激值、奖励期望和奖励预测误差的离散编码。

DOI:
10.1152/jn.00097.2015
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发表时间:
2015
影响因子:
2.5
通讯作者:
Tsutsui KI
Tsutsui KI
中科院分区:
医学3区
文献类型:
--
作者:
Oyama K;Tateyama Y;Hernadi I;Tobler PN;Iijima T;Tsutsui KI

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为了研究纹状体如何整合感官信息与奖励信息的行为指导,我们记录了单单位活动的背侧纹状体的头部固定大鼠参与概率巴甫洛夫条件反射任务与听觉条件刺激(CSs),其中奖励概率是固定的每个CS,但参数不同的CS。我们发现,许多神经元的活动与CS表示的奖励概率呈线性相关。记录的神经元可以根据其放电模式分为功能亚型编码奖励概率的不同形式,如刺激值,奖励期望,奖励预测误差。这些结果表明,背侧纹状体神经元的几个功能亚群代表了通过广泛的事先暴露于CS奖励突发事件形成的不同种类的信息。
To investigate how the striatum integrates sensory information with reward information for behavioral guidance, we recorded single-unit activity in the dorsal striatum of head-fixed rats participating in a probabilistic Pavlovian conditioning task with auditory conditioned stimuli (CSs) in which reward probability was fixed for each CS but parametrically varied across CSs. We found that the activity of many neurons was linearly correlated with the reward probability indicated by the CSs. The recorded neurons could be classified according to their firing patterns into functional subtypes coding reward probability in different forms such as stimulus value, reward expectation, and reward prediction error. These results suggest that several functional subgroups of dorsal striatal neurons represent different kinds of information formed through extensive prior exposure to CS-reward contingencies.
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