Variable maternal stress in rats alters locomotor activity, social behavior, and recognition memory in the adult offspring.
Variable maternal stress in rats alters locomotor activity, social behavior, and recognition memory in the adult offspring.
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DOI：
10.1016/j.pbb.2012.12.015
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发表时间：
2013-03
影响因子：
3.6
通讯作者：
Terry, Alvin V., Jr.
中科院分区：
文献类型：
--
作者：
Wilson, Christina A.;Terry, Alvin V., Jr.
关键词：
反复暴露于可变产前应激（PNS）的大鼠表现出与几种神经精神疾病相似的行为迹象，如注意力和抑制控制缺陷，以及记忆相关任务表现障碍。本研究的目的是进行一系列全面的测试，以进一步表征PNS大鼠的行为表型，并评估该模型对治疗干预（即先前显示具有治疗神经精神疾病潜力的化合物）的敏感性。本研究结果表明，PNS与大鼠的运动活动和刻板行为增加有关，2)对精神兴奋剂安非他明的敏感性增加，3)对成年和幼年大鼠的攻击行为增加，4)延迟依赖性识别记忆缺陷。没有证据表明PNS大鼠在运动功能/学习、感觉运动门控、空间学习和记忆、社交退缩或快感缺乏等其他领域表现出缺陷。此外，结果显示，第二代抗精神病药物利培酮减轻了安非他明相关的PNS大鼠运动活动的增加；然而，这种效果并没有持续一段时间。此外，去甲肾上腺素再摄取抑制剂阿托西汀可以减轻PNS大鼠的识别记忆缺陷，而α7烟碱乙酰胆碱受体部分激动剂GTS-21则不能。本研究支持了一种假设，即暴露于PNS的大鼠和患有神经精神疾病的患者之间存在重要的现象学相似性，从而进一步建立了评估潜在治疗干预措施的模型的表面有效性。
Rats repeatedly exposed to variable prenatal stress (PNS) exhibit behavioral signs that are similar to those manifested in several neuropsychiatric disorders such as deficits in attention and inhibitory control, and impairments in memory-related task performance. The purpose of the study described here was to conduct a comprehensive battery of tests to further characterize the behavioral phenotype of PNS rats as well as to evaluate the sensitivity of the model to therapeutic interventions (i.e., to compounds previously shown to have therapeutic potential in neuropsychiatric disorders). The results of this study indicated that PNS in rats is associated with: 1) increased locomotor activity and stereotypic behaviors, 2) elevated sensitivity to the psychostimulant amphetamine, 3) increased aggressive behaviors toward both adult and juvenile rats and 4) delay-dependent deficits in recognition memory. There was no evidence that PNS rats exhibited deficits in other areas of motor function/learning, sensorimotor gating, spatial learning and memory, social withdrawal, or anhedonia. In addition, the results revealed that the second generation antipsychotic risperidone attenuated amphetamine-related increases in locomotor activity in PNS rats; however, the effect was not sustained over time. Furthermore, deficits in recognition memory in PNS rats were attenuated by the norepinephrine reuptake inhibitor, atomoxetine, but not by the α7 nicotinic acetylcholine receptor partial agonist, GTS-21. This study supports the supposition that important phenomenological similarities exist between rats exposed to PNS and patients afflicted with neuropsychiatric disorders thus further establishing the face validity of the model for evaluating potential therapeutic interventions.
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影响因子：
3.3
作者：
Class QA;Lichtenstein P;Långström N;D'Onofrio BM
通讯作者：
D'Onofrio BM
影响因子：
3.7
作者：
Davis, Elysia Poggi;Sandman, Curt A.
通讯作者：
Sandman, Curt A.
影响因子：
2.7
作者：
ENNACEUR, A;DELACOUR, J
通讯作者：
DELACOUR, J
影响因子：
3.3
作者：
DIAZ, R;OGREN, SO;FUXE, K
通讯作者：
FUXE, K
影响因子：
4.7
作者：
Hohnadel, Elizabeth;Bouchard, Kristy;Terry, Alvin V., Jr.
通讯作者：
Terry, Alvin V., Jr.