Prenatal psychobiological predictors of anxiety risk in preadolescent children.
Prenatal psychobiological predictors of anxiety risk in preadolescent children.
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DOI：
10.1016/j.psyneuen.2011.12.016
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发表时间：
2012-08
影响因子：
3.7
通讯作者：
Sandman, Curt A.
中科院分区：
文献类型：
--
作者：
Davis, Elysia Poggi;Sandman, Curt A.
实验动物模型表明，产前压力的主要后果之一是后代的恐惧和焦虑增加。很少有前瞻性的人类研究评估了产前压力对青春期前焦虑的影响。本研究的目的是确定产前暴露于母体生物应激信号和心理困扰对青春期前儿童焦虑的影响。参与者包括178对母子。在妊娠19、25和31周时评估产妇的心理困扰（一般焦虑、感知压力、抑郁和妊娠特异性焦虑）和生物压力信号。使用儿童行为检查表对6至9岁的儿童进行焦虑评估。分析显示，产前暴露于母体皮质醇升高、抑郁、感知压力和妊娠特异性焦虑与儿童焦虑增加有关。在考虑了产科、社会人口学和产后产妇心理困扰等可能影响儿童发育的因素后，这些关联仍然存在。当所有的产前措施一起考虑，皮质醇和怀孕特定的焦虑独立预测儿童焦虑。暴露于产前母体皮质醇升高和妊娠特异性焦虑的儿童在青春期前出现焦虑问题的风险增加。该项目确定了与儿童心理健康的持久后果有关的产前风险因素，并提出了减少产前产妇痛苦将对儿童福祉产生长期效益的可能性。
Experimental animal models have demonstrated that one of the primary consequences of prenatal stress is increased fear and anxiety in the offspring. Few prospective human studies have evaluated the consequences of prenatal stress on anxiety during preadolescence. The purpose of this investigation is to determine the consequences of prenatal exposure to both maternal biological stress signals and psychological distress on anxiety in preadolescent children. Participants included 178 mother-child pairs. Maternal psychological distress (general anxiety, perceived stress, depression and pregnancy-specific anxiety) and biological stress signals were evaluated at 19, 25, and 31 gestational weeks. Anxiety was evaluated in the children at 6 to 9 years of age using the Child Behavior Checklist. Analyses revealed that prenatal exposure to elevated maternal cortisol, depression, perceived stress and pregnancy-specific anxiety was associated with increased anxiety in children. These associations remained after considering obstetric, sociodemographic and postnatal maternal psychological distress; factors that could influence child development. When all of the prenatal measures were considered together, cortisol and pregnancy-specific anxiety independently predicted child anxiety. Children exposed to elevated prenatal maternal cortisol and pregnancy-specific anxiety were at an increased risk for developing anxiety problems during the preadolescent period. This project identifies prenatal risk factors associated with lasting consequences for child mental health and raises the possibility that reducing maternal distress during the prenatal period will have long term benefits for child well-being.
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DOI：
10.3109/10253890.2011.623250
发表时间：
2011-11
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Buss C;Davis EP;Hobel CJ;Sandman CA
通讯作者：
Sandman CA
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
168.9
作者：
Gitau, R;Cameron, A;Glover, V
通讯作者：
Glover, V
DOI：
10.1111/j.1469-7610.2008.01987.x
发表时间：
2008-10-01
影响因子：
7.6
作者：
Bergman, K.;Sarkar, P.;O'Connor, T. G.
通讯作者：
O'Connor, T. G.
影响因子：
4.8
作者：
Brown, RW;Diaz, R;Seckl, JR
通讯作者：
Seckl, JR