Zinc-Modified Sulfonated Polyetheretherketone Surface with Immunomodulatory Function for Guiding Cell Fate and Bone Regeneration.
Zinc-Modified Sulfonated Polyetheretherketone Surface with Immunomodulatory Function for Guiding Cell Fate and Bone Regeneration.
复制标题
具有免疫调节功能的锌改性磺化聚醚醚酮表面，用于指导细胞命运和骨再生
DOI：
10.1002/advs.201800749
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Liu W;Li J;Cheng M;Wang Q;Yeung KWK;Chu PK;Zhang X
免疫细胞释放的细胞因子被认为是诱导骨组织再生的重要因素。然而，这些骨靶向巨噬细胞因子在组织微环境下由生物材料表面诱导的途径很少报道。本研究探讨锌离子对巨噬细胞极化的免疫调节作用及其对成骨分化的影响。因此，通过使用定制的磁控溅射技术在磺化聚醚醚酮（SPEEK）生物材料上掺入锌离子层。结果表明，锌涂层SPEEK上的微环境可以调节非活化巨噬细胞极化为抗炎表型，并诱导抗炎和成骨细胞因子的分泌。因此，骨髓基质细胞（BMSC）的成骨分化能力得到增强，从而改善了镀锌SPEEK与骨组织之间的骨整合。本研究验证了锌离子在骨免疫调节过程中是一种有前途的添加剂，并为开发下一代免疫调节生物材料铺平了道路。
The cytokines released by immune cells are considered important factors to induce bone tissue regeneration. However, the pathway of those bone‐targeting macrophage cytokines induced by biomaterial surface under tissue microenvironment is rarely reported. In this study, the immunomodulatory capability of zinc ions on macrophage polarization and its effects on osteogenic differentiation are investigated. Hence, a layer of zinc ions are incorporated on sulfonated polyetheretherketone (SPEEK) biomaterials by using a customized magnetron sputtering technique. The results reveal that the microenvironment on Zn‐coated SPEEK can modulate nonactivated macrophage polarization to an anti‐inflammatory phenotype and induce the secretion of anti‐inflammatory and osteogenic cytokines. The osteogenic differentiation capability of bone marrow stromal cells (BMSCs) is therefore enhanced, leading to improved osteointegration between the zinc‐coated SPEEK and bone tissue. This study verifies that zinc ion is a promising additive in the osteoimmunomodulation process and provides knowledge that may pave the way to develop the next generation of immunomodulatory biomaterials.
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影响因子：
14
作者：
Chen, Sulin;Jones, Jacqueline A.;Xu, Yongan;Low, Hong-Yee;Anderson, James M.;Leong, Kam W.
通讯作者：
Leong, Kam W.
锌信号在免疫系统中的作用。
影响因子：
4.1
作者：
Hojyo S;Fukada T
通讯作者：
Fukada T
影响因子：
4.2
作者：
Hambidge, K. Michael;Krebs, Nancy F.
通讯作者：
Krebs, Nancy F.
影响因子：
24.2
作者：
Chen, Zetao;Klein, Travis;Xiao, Yin
通讯作者：
Xiao, Yin
影响因子：
10
作者：
Boddupalli, Anuraag;Zhu, Lida;Bratlie, Kaitlin M.
通讯作者：
Bratlie, Kaitlin M.