Stability of autistic traits in the general population: further evidence for a continuum of impairment.
Stability of autistic traits in the general population: further evidence for a continuum of impairment.
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DOI：
10.1016/j.jaac.2011.01.005
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发表时间：
2011-04
影响因子：
13.3
通讯作者：
Koenen KC
中科院分区：
文献类型：
--
作者：
Robinson EB;Munir K;Munafò MR;Hughes M;McCormick MC;Koenen KC
本研究调查了全国代表性的7 ~ 13岁儿童自闭症特征的发展历程。在雅芳父母与儿童纵向研究（ALSPAC）中，6539名儿童的父母在7岁、10岁和13岁时完成了社交和沟通障碍检查表（SCDC）。在全样本和高分个体（如前10%，前5%）中评估自闭症特征的表型进展。性别、智商和整体行为困难作为自闭症特质轨迹的潜在相关影响进行了研究。自闭症特征在一般人群中是高度稳定的，无论是在总体上还是在得分较高的群体中。在整个样本中，7至13岁女性的平均SCDC评分没有变化（p=0.43）。男性得分略有下降，但显著下降，约为0.1标准差（p<0.001）。在任何高得分组中，父母评定的自闭症特征没有平均变化。智商与表型进展无关；高父母评价的行为问题预示着高得分个体在研究期间SCDC得分的轻微改善（p<0.01）。这些发现表明，自闭症特征在一般人群中是高度稳定的，即使是在自闭症样行为最集中的个体中也是如此。表型稳定性与对ASD个体的预期一致，为跨临床阈值的现象连续体提供了进一步的支持。此外，女性和男性患自闭症症状的风险差距随着时间的推移是一致的。
This study investigated the developmental course of autistic traits in a nationally-representative sample between ages 7 and 13. The parents of 6,539 children in the Avon Longitudinal Study of Parents and Children (ALSPAC) completed the Social and Communication Disorders Checklist (SCDC) at ages 7, 10, and 13. The phenotypic progression of autistic traits was assessed in the full sample and among high scoring individuals (e.g. top 10%, 5%). Gender, IQ, and overall behavior difficulties were examined as potentially relevant influences on autistic trait trajectories. Autistic traits were highly stable in the general population, both overall and in high scoring groups. In the full sample, there was no change in mean SCDC scores for females between ages 7 and 13 (p=0.43). Male scores decreased slightly, but significantly, on the order of 0.1 standard deviations (p<0.001). There was no mean change in parent-rated autistic traits within any of the high scoring groups. IQ was not related to phenotypic progression; high parent-rated behavior problems predicted slight improvement in SCDC scores over the course of the study period among high scoring individuals (p<0.01). These findings suggest that autistic traits are highly stable in the general population, even among individuals with the highest concentrations of autism-like behaviors. Phenotypic stability is consistent with expectations for individuals with ASD, providing further support for a phenomenological continuum across the clinical threshold. Moreover, the gap between female and male risk for autistic symptomology is consistent over time.
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影响因子：
3.3
作者：
Constantino, John N.;Abbacchi, Anna M.;Lavesser, Patricia D.;Reed, Hannah;Givens, Leah;Chiang, Lily;Gray, Teddi;Gross, Maggie;Zhang, Yi;Todd, Richard D.
通讯作者：
Todd, Richard D.
影响因子：
5
作者：
Glymour, MM;Weuve, J;Robins, JM
通讯作者：
Robins, JM
DOI：
10.1002/ajmg.b.31066
发表时间：
2010-07-01
影响因子：
2.8
作者：
Hoekstra, Rosa A.;Happe, Francesca;Ronald, Angelica
通讯作者：
Ronald, Angelica
影响因子：
10.5
作者：
Skuse, DH;Mandy, WPL;Scourfield, J
通讯作者：
Scourfield, J
影响因子：
--
作者：
Lord, C;Risi, S;Pickles, A
通讯作者：
Pickles, A