RCAS1 as a tumour progression marker: an independent negative prognostic factor in gallbladder cancer.
RCAS1 as a tumour progression marker: an independent negative prognostic factor in gallbladder cancer.
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DOI：
10.1054/bjoc.2001.2192
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发表时间：
2001-12-14
影响因子：
8.8
通讯作者：
Katoh H
中科院分区：
文献类型：
--
作者：
Oshikiri T;Hida Y;Miyamoto M;Hashida H;Katoh K;Suzuoki M;Nakakubo Y;Hiraoka K;Shinohara T;Itoh T;Kondo S;Katoh H
Siso细胞上表达的受体结合肿瘤抗原(RCAS1)可诱导携带RCAS1受体的免疫细胞的凋亡。我们试图确定RCAS1在胆囊癌的发生和发展中的作用，以及RCAS1对患者生存的影响。应用免疫组织化学方法检测110例手术切除的胆囊癌组织中RCAS1的表达。其中胆囊炎20例，胆囊炎合并胰胆管连接不良23例，腺肌瘤14例，腺瘤7例，癌症46例。RCAS1(在超过25%的细胞中免疫反应)在46例癌症中有32例(70%)高表达，但在包括癌前病变在内的其他疾病中未见表达。RCAS1阳性表达与肿瘤侵袭深度(P=0.0180)、淋巴结转移(P=0.0033)、淋巴转移(P=0.0104)、静脉侵犯(P=0.0224)、神经周围侵犯(P=0.0351)和肿瘤分期(P=0.0026)有关。因此，RCAS1的表达在胆囊癌发生过程中可能是一个相对较晚的事件，可能促进了肿瘤的进展。COX回归多因素分析显示RCAS1阳性是影响患者生存的独立负性预测因素(P=0.0337；风险比12.690；95%可信区间1.216-132.423)。RCAS1的高表达与胆囊癌的肿瘤进展和预后不良显著相关。©2001癌症研究活动http://www.bjcancer.com
Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) induces apoptosis in immune cells bearing the RCAS1 receptor. We sought to determine RCAS1 involvement in the origin and progression of gallbladder cancer, and also implications of RCAS1 for patient survival. RCAS1 expression was examined immunohistochemically in 110 surgically resected gallbladder specimens. The gallbladders represented 20 cases of cholecystitis with no associated pancreaticobiliary maljunction; 23 cases of cholecystitis with pancreaticobiliary maljunction; 14 cases of adenomyomatosis; 7 adenomas; and 46 cancers. High expression of RCAS1 (immunoreactivity in over 25% of cells) was observed in 32 of the 46 cancers (70%), but not in other diseases, including pre-cancerous conditions. RCAS1 immunoreactivity was associated with depth of tumour invasion (P = 0.0180), lymph node metastasis (P = 0.0033), lymphatic involvement (P = 0.0104), venous involvement (P = 0.0224), perineural involvement (P = 0.0351) and stage by the tumour, nodes and metastases (TNM) classification (P = 0.0026). Thus, RCAS1 expression may be a relatively late event in gallbladder carcinogenesis possibly promoting tumour progression. Cox regression multivariate analysis demonstrated RCAS1 positivity to be an independent negative predictor for survival (P = 0.0337; risk ratio, 12.690; 95% confidence interval, 1.216–132.423). High expression of RCAS1 significantly correlated with tumour progression and predicted poor outcome in gallbladder cancer. © 2001 Cancer Research Campaign http://www.bjcancer.com
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影响因子：
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