Spatial and temporal variation in the community prevalence of antibiotic resistance in Bangladesh: an integrated surveillance study protocol.
Spatial and temporal variation in the community prevalence of antibiotic resistance in Bangladesh: an integrated surveillance study protocol.
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DOI：
10.1136/bmjopen-2018-023158
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发表时间：
2018-04-28
期刊：
影响因子：
2.9
通讯作者：
Islam MA
中科院分区：
文献类型：
--
作者：
Rousham E;Unicomb L;Wood P;Smith M;Asaduzzaman M;Islam MA
在孟加拉国等低收入和中等收入国家，抗生素耐药性（ABR）的增加构成了重大的健康威胁。然而，在缺乏关于社区耐药细菌流行率的可靠数据的情况下，评估健康风险的规模是有问题的。我们描述了一个小规模的综合监测计划，旨在量化的流行率与耐药细菌和耐药基因的浓度从“一个健康”的角度来看殖民的协议。对孟加拉国城市和农村的人类、动物和环境中的ABR进行全面评估，将产生全面的数据，为人类健康风险提供信息。研究设计集中在三个与安全性相关的地点，这些地点存在ABR在人、动物和环境之间传播的增强潜力：（1）农村家禽饲养家庭，（2）商业家禽养殖场和（3）城市活禽市场。在高和低暴露于农业和家禽的人群中比较ABR的流行率将使我们能够测试来自环境和食用动物的ABR细菌和基因是传播给人类的潜在来源的假设。大肠杆菌被用作ABR指示生物，因为它广泛存在于环境中，并在人类和动物胃肠道中定殖。该研究已获得孟加拉国国际腹泻病研究中心机构审查委员会和拉夫堡大学伦理委员会的批准。该项目的数据将储存在自然环境研究理事会生态和水文中心的开放存取储存库中。这项研究的结果将发表在同行评审的期刊上，并在国家和国际会议上发表。
Increasing antibiotic resistance (ABR) in low-income and middle-income countries such as Bangladesh presents a major health threat. However, assessing the scale of the health risk is problematic in the absence of reliable data on the community prevalence of antibiotic-resistant bacteria. We describe the protocol for a small-scale integrated surveillance programme that aims to quantify the prevalence of colonisation with antibiotic-resistant bacteria and concentrations of antibiotic-resistant genes from a ‘One Health’ perspective. The holistic assessment of ABR in humans, animals and within the environment in urban and rural Bangladesh will generate comprehensive data to inform human health risk. The study design focuses on three exposure-relevant sites where there is enhanced potential for transmission of ABR between humans, animals and the environment: (1) rural poultry-owning households, (2) commercial poultry farms and (3) urban live-bird markets. The comparison of ABR prevalence in human groups with high and low exposure to farming and poultry will enable us to test the hypothesis that ABR bacteria and genes from the environment and food-producing animals are potential sources of transmission to humans. Escherichia coli is used as an ABR indicator organism due to its widespread environmental presence and colonisation in both the human and animal gastrointestinal tract. The study has been approved by the Institutional Review Board of the International Centre for Diarrhoeal Disease Research, Bangladesh, and Loughborough University Ethics Committee. Data for the project will be stored on the open access repository of the Centre for Ecology and Hydrology, Natural Environment Research Council. The results of this study will be published in peer-reviewed journals and presented at national and international conferences.
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影响因子：
168.9
作者：
Holmes, Alison H.;Moore, Luke S. P.;Piddock, Laura J. V.
通讯作者：
Piddock, Laura J. V.
影响因子：
4.8
作者：
Braykov NP;Eisenberg JN;Grossman M;Zhang L;Vasco K;Cevallos W;Muñoz D;Acevedo A;Moser KA;Marrs CF;Foxman B;Trostle J;Trueba G;Levy K
通讯作者：
Levy K
影响因子：
11.4
作者：
Ercumen A;Pickering AJ;Kwong LH;Arnold BF;Parvez SM;Alam M;Sen D;Islam S;Kullmann C;Chase C;Ahmed R;Unicomb L;Luby SP;Colford JM Jr
通讯作者：
Colford JM Jr
影响因子：
3.3
作者：
Luby, Stephen P.;Halder, Amal K.;Johnston, Richard B.
通讯作者：
Johnston, Richard B.
影响因子：
56.3
作者：
Liu, Yi-Yun;Wang, Yang;Shen, Jianzhong
通讯作者：
Shen, Jianzhong