Obesity and Pancreatic Cancer: Recent Progress in Epidemiology, Mechanisms and Bariatric Surgery.
Obesity and Pancreatic Cancer: Recent Progress in Epidemiology, Mechanisms and Bariatric Surgery.
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DOI：
10.3390/biomedicines10061284
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发表时间：
2022-05-31
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
在美国，超过30%的人被归类为肥胖，超过50%的人被认为是明显超重。重要的是，肥胖不仅是代谢综合征发展的危险因素，也是许多癌症的危险因素，包括胰腺导管腺癌（PDAC）。PDAC是癌症相关死亡的第三大原因，在美国PDAC的5年生存率保持在9%左右。肥胖是PDAC的已知风险因素。代谢控制和减肥手术，这是一种有效的治疗严重肥胖，并允许大量的体重减轻，已被证明可以降低PDAC的风险。因此，很明显，阐明肥胖和PDAC之间的联系对于识别肥胖相关PDAC风险的新标记物和/或干预点是重要的。在这篇综述中，我们讨论了肥胖相关PDAC的流行病学，机制和干预措施的潜在癌症预防效果，包括减肥手术的临床前和临床研究的最新进展。
More than 30% of people in the United States (US) are classified as obese, and over 50% are considered significantly overweight. Importantly, obesity is a risk factor not only for the development of metabolic syndrome but also for many cancers, including pancreatic ductal adenocarcinoma (PDAC). PDAC is the third leading cause of cancer-related death, and 5-year survival of PDAC remains around 9% in the U.S. Obesity is a known risk factor for PDAC. Metabolic control and bariatric surgery, which is an effective treatment for severe obesity and allows massive weight loss, have been shown to reduce the risk of PDAC. It is therefore clear that elucidating the connection between obesity and PDAC is important for the identification of a novel marker and/or intervention point for obesity-related PDAC risk. In this review, we discussed recent progress in obesity-related PDAC in epidemiology, mechanisms, and potential cancer prevention effects of interventions, including bariatric surgery with preclinical and clinical studies.
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影响因子：
7.7
作者：
Andersen DK;Korc M;Petersen GM;Eibl G;Li D;Rickels MR;Chari ST;Abbruzzese JL
通讯作者：
Abbruzzese JL
影响因子：
9.3
作者：
Almeida, Shone O.;Budoff, Matthew
通讯作者：
Budoff, Matthew
影响因子：
18.2
作者：
Campisi J
通讯作者：
Campisi J
DOI：
10.1093/jnci/djx012
发表时间：
2017-09-01
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Carreras-Torres R;Johansson M;Gaborieau V;Haycock PC;Wade KH;Relton CL;Martin RM;Davey Smith G;Brennan P
通讯作者：
Brennan P
影响因子：
4.6
作者：
Chang HH;Moro A;Chou CEN;Dawson DW;French S;Schmidt AI;Sinnett-Smith J;Hao F;Hines OJ;Eibl G;Rozengurt E
通讯作者：
Rozengurt E