Resurgence of SARS-CoV-2: Detection by community viral surveillance.
Resurgence of SARS-CoV-2: Detection by community viral surveillance.
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DOI：
10.1126/science.abf0874
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发表时间：
2021-05-28
期刊：
影响因子：
--
通讯作者：
Elliott P
中科院分区：
文献类型：
--
作者：
Riley S;Ainslie KEC;Eales O;Walters CE;Wang H;Atchison C;Fronterre C;Diggle PJ;Ashby D;Donnelly CA;Cooke G;Barclay W;Ward H;Darzi A;Elliott P
即使是高效的疫苗也不能使我们免于监测严重急性呼吸综合征冠状病毒2(SARS-CoV-2)活动的需要，可能在未来几年内。公共卫生机构将需要对病例的任何上升进行预警，以便根据需要准备和部署干预措施。莱利等人。开发了一个社区范围的计划，旨在检测低流行率下的卷土重来，并已用于跟踪整个英格兰的SARS-CoV-2病毒。在2020年5月至9月的四轮抽样中，对所有社区的近60万名代表进行了监测。结果显示，18至24岁人群的感染率最高，老年人群的发病率不断上升，一些社区的感染几率也有所上升。这一检测方法为监测SARS-CoV-2需要进行的实时、全国范围内的人口监测工作提供了一种模式。科学，abf0874，本期第990页具有代表性的社区抗原采样可以提高对情况的认识，并帮助评估SARS-CoV-2低流行率的干预措施。严重急性呼吸综合征冠状病毒2(SARS-CoV-2)疫情的监测主要依靠病例报告，而病例报告受到卫生服务绩效、检测可获得性和寻求检测行为的影响。我们报告了英国的一个具有社区代表性的监测项目，该项目基于2020年5月至9月初期间约594,000名接受SARS-CoV-2检测的个人的自我拭子结果，无论症状如何。疫情在2020年5月至7月期间有所下降，但随后从8月中旬开始逐渐上升，并在第二波疫情开始时加速至2020年9月初。与通过常规监测发现的病例相比，我们在这里报告的下降时间更长，年龄分布更年轻。具有代表性的SARS-CoV-2社区抽样即使在低流行率的情况下也可以显著提高对情况的认识，并提供给公共卫生应对措施。
Even highly effective vaccines will not save us from the need to monitor severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) activity, perhaps for years to come. Public health institutions will need early warning of any uptick in cases to prepare and deploy interventions as required. Riley et al. developed a community-wide program that was designed to detect resurgence at low prevalence and has been used to track SARS-CoV-2 virus across England. In the four rounds of sampling from May to September 2020, almost 600,000 people representative of all communities were monitored. The results revealed the greatest prevalence among 18- to 24-year-olds, with increasing incidence among older age groups and elevated odds of infection among some communities. This testing approach offers a model for the type of real-time, country-wide population-based surveillance work that needs to be conducted to monitor SARS-CoV-2. Science, abf0874, this issue p. 990 Representative community antigen sampling can improve situational awareness and help evaluate interventions at low SARS-CoV-2 prevalence. Surveillance of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has mainly relied on case reporting, which is biased by health service performance, test availability, and test-seeking behaviors. We report a community-wide national representative surveillance program in England based on self-administered swab results from ~594,000 individuals tested for SARS-CoV-2, regardless of symptoms, between May and the beginning of September 2020. The epidemic declined between May and July 2020 but then increased gradually from mid-August, accelerating into early September 2020 at the start of the second wave. When compared with cases detected through routine surveillance, we report here a longer period of decline and a younger age distribution. Representative community sampling for SARS-CoV-2 can substantially improve situational awareness and feed into the public health response even at low prevalence.
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DOI：
10.1016/j.jinf.2020.05.073
发表时间：
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期刊：
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