An fMRI study of affective perspective taking in individuals with psychopathy: imagining another in pain does not evoke empathy.
An fMRI study of affective perspective taking in individuals with psychopathy: imagining another in pain does not evoke empathy.
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DOI：
10.3389/fnhum.2013.00489
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发表时间：
2013
影响因子：
2.9
通讯作者：
Kiehl KA
中科院分区：
文献类型：
--
作者：
Decety J;Chen C;Harenski C;Kiehl KA
虽然人们已经确定，精神病患者在情感唤起、情感移情和关心他人福祉方面存在明显缺陷，但观点采择在多大程度上可以引发情感反应尚未得到研究，尽管它在康复方面有潜在的应用。在健康的个体中，情感观点采择已被证明是引发同情和关心他人的有效手段。为了研究在情感观点采择过程中不同精神病态个体的神经反应，121名被监禁的男性，被归类为高（n = 37; Hare精神病检查表-修订版，PCL-R ≥ 30），中度（n = 44; PCL-R介于21和29之间），低（n = 40; PCL-R ≤ 20）精神病患者，在观看描述身体伤害的刺激并采用想象自我和想象他人视角时进行扫描。在想象-自我视角中，高精神病患者表现出与疼痛共情相关的网络内的典型反应，包括前额叶（aINS），前中扣带皮层（aMCC），辅助运动区（SMA），额下回（IFG），体感皮层和右杏仁核。相反，在想象-他人视角中，精神病患者表现出一种非典型的大脑激活模式，并且在前额叶和杏仁核中与眶额皮质（OFC）和腹内侧前额叶皮质（vmPFC）建立了有效的连接。杏仁核和杏仁核的反应与PCL-R因子1（人际/情感）呈负相关。在高精神病患者中，PCL-R因子1的分数预测了腹侧纹状体在想象他人痛苦时的神经反应。这些与不同观点采择相关的大脑激活和有效连接模式，提供了对精神病患者共情功能障碍的更好理解，并有可能为这一复杂临床问题的干预计划提供信息。
While it is well established that individuals with psychopathy have a marked deficit in affective arousal, emotional empathy, and caring for the well-being of others, the extent to which perspective taking can elicit an emotional response has not yet been studied despite its potential application in rehabilitation. In healthy individuals, affective perspective taking has proven to be an effective means to elicit empathy and concern for others. To examine neural responses in individuals who vary in psychopathy during affective perspective taking, 121 incarcerated males, classified as high (n = 37; Hare psychopathy checklist-revised, PCL-R ≥ 30), intermediate (n = 44; PCL-R between 21 and 29), and low (n = 40; PCL-R ≤ 20) psychopaths, were scanned while viewing stimuli depicting bodily injuries and adopting an imagine-self and an imagine-other perspective. During the imagine-self perspective, participants with high psychopathy showed a typical response within the network involved in empathy for pain, including the anterior insula (aINS), anterior midcingulate cortex (aMCC), supplementary motor area (SMA), inferior frontal gyrus (IFG), somatosensory cortex, and right amygdala. Conversely, during the imagine-other perspective, psychopaths exhibited an atypical pattern of brain activation and effective connectivity seeded in the anterior insula and amygdala with the orbitofrontal cortex (OFC) and ventromedial prefrontal cortex (vmPFC). The response in the amygdala and insula was inversely correlated with PCL-R Factor 1 (interpersonal/affective) during the imagine-other perspective. In high psychopaths, scores on PCL-R Factor 1 predicted the neural response in ventral striatum when imagining others in pain. These patterns of brain activation and effective connectivity associated with differential perspective-taking provide a better understanding of empathy dysfunction in psychopathy, and have the potential to inform intervention programs for this complex clinical problem.
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影响因子：
25.8
作者：
Decety, Jean;Skelly, Laurie R.;Kiehl, Kent A.
通讯作者：
Kiehl, Kent A.
影响因子：
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通讯作者：
Zald, David H.
影响因子：
5.4
作者：
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Decety, Jean
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2
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