Brain response to empathy-eliciting scenarios involving pain in incarcerated individuals with psychopathy.
Brain response to empathy-eliciting scenarios involving pain in incarcerated individuals with psychopathy.
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DOI：
10.1001/jamapsychiatry.2013.27
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发表时间：
2013-06
期刊：
影响因子：
25.8
通讯作者：
Kiehl, Kent A.
中科院分区：
文献类型：
--
作者：
Decety, Jean;Skelly, Laurie R.;Kiehl, Kent A.
明显缺乏同情心是精神病患者的一个标志性特征。然而，与移情处理相关的神经反应尚未在精神病患者中得到直接研究，特别是在对他人痛苦和痛苦的感知方面。确定在感知描绘其他人疼痛的共情诱发刺激时，被监禁的精神病患者和被监禁的对照组的神经活动模式的潜在差异。在一项病例对照研究中，在被监禁的精神病患者和被监禁的对照组之间比较了由描绘个体受到伤害和疼痛的面部表情的动态刺激引起的大脑激活模式。参与者被扫描的理由，一个惩教设施使用的头脑研究网络的移动的1.5 T磁共振成像系统。根据修订的Hare精神病检查表（PCL-R）的评分，将80名被监禁的男性分为精神病高（n = 27; PCL-R =30），中等（n = 28; PCL-R在21-29之间）和低（n = 25; PCL-R ≤20）。功能性磁共振成像揭示的移情诱发动态情景的神经血液动力学反应。与对照组相比，精神病患者的腹内侧前额叶皮质、外侧眶额皮质和导水管周围灰质的激活明显较少，但脑岛的激活较多。在响应他人表达的疼痛线索，精神病患者表现出的VMPFC和OFC的赤字，无论刺激类型，但显示选择性损害与认知心理化相关的区域在处理面部线索的痛苦。
A marked lack of empathy is a hallmark characteristic of individuals with psychopathy. However, neural response associated to empathic processing has not yet been directly examined in psychopathy especially in response to the perception of other people in pain and distress. To identify potential differences in patterns of neural activity in incarcerated psychopaths and incarcerated controls during the perception of empathy-eliciting stimuli depicting other people in pain. In a case-control study, brain activation patterns elicited by dynamic stimuli depicting individuals being harmed and facial expression of pain were compared between incarcerated psychopaths and incarcerated controls. Participants were scanned in on the grounds of a correctional facility using the Mind Research Network's mobile 1.5 T MRI system. Eighty incarcerated males were classified according to scores on the Hare Psychopathy Checklist-Revised (PCL-R) as high (n = 27; PCL-R =30), intermediate (n = 28; PCL-R between 21–29), or low (n = 25; PCL-R ≤20) on psychopathy. Neuro-hemodynamic response to empathy-eliciting dynamic scenarios revealed by functional magnetic resonance imaging. Psychopaths exhibited significantly less activation in the ventromedial prefrontal cortex, lateral orbitofrontal cortex, and periaqueductal gray relative to controls, but showed greater activation in the insula. In response to pain cues expressed by others, psychopaths exhibit deficits in vmPFC and OFC regardless of stimulus type, but display selective impairment in processing facial cues of distress in regions associated with cognitive mentalizing.
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影响因子：
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