Dissociated regulation of growth and ornithine decarboxylase activity by estrogen in the rat uterus.
Dissociated regulation of growth and ornithine decarboxylase activity by estrogen in the rat uterus.
复制标题
雌激素对大鼠子宫生长和鸟氨酸脱羧酶活性的分离调节。
DOI：
10.1016/0006-291x(84)91217-8
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发表时间：
1984
影响因子：
3.1
通讯作者：
Katzenellenbogen,BS
中科院分区：
文献类型：
--
作者：
Rorke,EA;Katzenellenbogen,BS
To evaluate the role of polyamines in mediating the effect of estrogen on growth of the rat uterus, we examined the effect of an irreversible inhibitor of ornithine decar☐ylase (ODC), 5α-difluoromethylornithine (DFMO), on estrogen-stimulated uterine growth. Estradiol alone evoked two major surges of ODC activity at 5 h and at 16 h, and 2-fold increases in the concentration of spermidine in the uterus. When DFMO was administered to either intact or ovariectomized immature (20 day-old) rats for 2 or 6 days prior to and then during the 1 or 3 days of estradiol treatment, uterine ODC activity was completely suppressed as was the associated increase in spermidine concentration, but the magnitude of uterine growth stimulated by estradiol was equally great in the presence or absence of DFMO. These observations suggest that although uterine growth stimulation by estrogen is normally accompanied by marked increases in ODC activity and spermidine accumulation, these changes are not essential for hormonally regulated uterine cell proliferationin vivo.
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雌二醇-17-β刺激后去势大鼠子宫中多胺的合成和积累。
影响因子：
4.8
作者：
D. Russell;R. Taylor
通讯作者：
R. Taylor
雌二醇处理的去势雄性大鼠肾脏中鸟氨酸脱羧酶的诱导和多胺水平。
影响因子：
6.1
作者：
H. Nawata;R. S. Yamamoto;L. Poirier
通讯作者：
L. Poirier
促甲状腺素体外刺激甲状腺鸟氨酸脱羧酶活性和多胺。
影响因子：
4.8
作者：
S. Scheinman;G. Burrow
通讯作者：
G. Burrow
α-二氟甲基鸟氨酸（一种酶激活的不可逆抑制剂或鸟氨酸脱羧酶）对睾酮诱导的去势大鼠前列腺和精囊再生的影响。
影响因子：
4.1
作者：
C. Danzin;M. Jung;N. Claverie;J. Grove;A. Sjoerdsma;J. Koch
通讯作者：
J. Koch
非洲爪蟾卵母细胞减数分裂成熟过程中鸟氨酸脱羧酶活性增加。
DOI：
--
发表时间：
1980
期刊：
Biochemical and Biophysical Research Communications - BBRC
影响因子：
--
作者：
E. Younglai;F. Godeau;J. Mester;E. Baulieu
通讯作者：
E. Baulieu