Genome sequence of erythromelalgia-related poxvirus identifies it as an ectromelia virus strain.

Genome sequence of erythromelalgia-related poxvirus identifies it as an ectromelia virus strain.
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DOI:
10.1371/journal.pone.0034604
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发表时间:
2012
期刊:
影响因子:
3.7
通讯作者:
Moss B
Moss B
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Mendez-Rios JD;Martens CA;Bruno DP;Porcella SF;Zheng ZM;Moss B

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红斑狼疮是一种以极端的灼热、疼痛和炎症发作为特征的疾病。这种综合征的流行形式发生在中国农村的中学生中,据报道,1987年从咽拭子中发现了一种被称为红斑性肢痛症相关痘病毒的病毒。当时进行的研究表明,ERPV属于正痘病毒属,与鼠痘的病原体--皮疹病毒有相似之处。我们已经测定了ERPV的全基因组序列,并证明它与ECtromelia病毒海军株的同源性为99.8%,与莫斯科株的同源性略低。海军基因组中没有ERPV的微小DNA缺失可能表明,被测序的Naval菌株不是ERPV的直接祖先。
Erythromelagia is a condition characterized by attacks of burning pain and inflammation in the extremeties. An epidemic form of this syndrome occurs in secondary students in rural China and a virus referred to as erythromelalgia-associated poxvirus (ERPV) was reported to have been recovered from throat swabs in 1987. Studies performed at the time suggested that ERPV belongs to the orthopoxvirus genus and has similarities with ectromelia virus, the causative agent of mousepox. We have determined the complete genome sequence of ERPV and demonstrated that it has 99.8% identity to the Naval strain of ectromelia virus and a slighly lower identity to the Moscow strain. Small DNA deletions in the Naval genome that are absent from ERPV may suggest that the sequenced strain of Naval was not the immediate progenitor of ERPV.
DOI: 10.1093/nar/gkq313
发表时间: 2010-07
影响因子: 14.9
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