Fibroinflammatory Signatures Increase with Age in the Human Ovary and Follicular Fluid.
Fibroinflammatory Signatures Increase with Age in the Human Ovary and Follicular Fluid.
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DOI：
10.3390/ijms22094902
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发表时间：
2021-05-05
影响因子：
5.6
通讯作者：
Duncan FE
中科院分区：
文献类型：
--
作者：
Machlin JH;Barishansky SJ;Kelsh J;Larmore MJ;Johnson BW;Pritchard MT;Pavone ME;Duncan FE
The female reproductive system ages before any other organ system in the body. This phenomenon can have tangible clinical implications leading to infertility, miscarriages, birth defects and systemic deterioration due to estrogen loss. “Fibroinflammation” is a hallmark of aging tissues; there is an increase in inflammatory cytokines and fibrotic tissue in the aging ovarian stroma. We systematically evaluated immunomodulatory factors in human follicular fluid, which, like the stroma, is a critical ovarian microenvironment directly influencing the oocyte. Using a cytokine antibody array, we identified a unique fibroinflammatory cytokine signature in follicular fluid across an aging series of women (27.7–44.8 years). This signature (IL-3, IL-7, IL-15, TGFβ1, TGFβ3 and MIP-1) increased with chronologic age, was inversely correlated to anti-Müllerian hormone (AMH) levels, and was independent of body mass index (BMI). We focused on one specific protein, TGFβ3, for further validation. By investigating this cytokine in human cumulus cells and ovarian tissue, we found that the age-dependent increase in TGFβ3 expression was unique to the ovarian stroma but not other ovarian sub-compartments. This study broadens our understanding of inflammaging in the female reproductive system and provides a defined fibroinflammatory aging signature in follicular fluid and molecular targets in the ovary with potential clinical utility.
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影响因子：
13.6
作者：
Freund A;Orjalo AV;Desprez PY;Campisi J
通讯作者：
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DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
6.7
作者：
Friedman, CI;Danforth, DR;Seifer, DB
通讯作者：
Seifer, DB
DOI：
10.1530/rep-16-0129
发表时间：
2016-09
期刊：
Reproduction (Cambridge, England)
影响因子：
--
作者：
Briley SM;Jasti S;McCracken JM;Hornick JE;Fegley B;Pritchard MT;Duncan FE
通讯作者：
Duncan FE
DOI：
10.5772/66405
发表时间：
2017-01-01
期刊：
PHYSIOLOGIC AND PATHOLOGIC ANGIOGENESIS - SIGNALING MECHANISMS AND TARGETED THERAPY
影响因子：
--
作者：
Guerrero, Paola A.;McCarty, Joseph H.
通讯作者：
McCarty, Joseph H.