Preclinical evaluation of the effect of periodontal regeneration by carbonate apatite in a canine one-wall intrabony defect model.
Preclinical evaluation of the effect of periodontal regeneration by carbonate apatite in a canine one-wall intrabony defect model.
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临床前评估碳酸盐磷灰石在犬一壁内部缺陷模型中对牙周再生的影响。
DOI：
10.1016/j.reth.2023.01.002
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发表时间：
2023-03
影响因子：
4.3
通讯作者：
Iwata, Takanori
中科院分区：
文献类型：
--
作者：
Takeuchi, Shunsuke;Fukuba, Shunsuke;Okada, Munehiro;Nohara, Kohei;Sato, Ryo;Yamaki, Daichi;Matsuura, Takanori;Hoshi, Shu;Aoki, Kazuhiro;Iwata, Takanori
本研究旨在从组织学上比较开放式皮瓣清创术、β-磷酸三钙（β-TCP）和碳酸磷灰石（CO 3Ap）治疗犬单壁骨内缺损的牙周再生。拔除4只比格犬下颌第三前磨牙。拔除后12周，在下颌第二前磨牙远中侧和第四前磨牙近中侧分别造成4 mm × 5 mm（近远中宽×深）的单壁骨缺损。将每个缺损随机分配到开放皮瓣清创术（对照组），使用β-TCP或CO 3Ap进行牙周再生。术后8周，进行组织学和组织计量学分析。在任何实验部位均未观察到关节强直、感染或急性炎症。所有实验组均有新生骨和牙骨质形成。CO 3Ap组牙槽骨嵴的矿物沉积率高于对照组和β-TCP组。CO 3Ap组新生骨面积比明显高于对照组（P < 0.05）。CO 3Ap组骨接触率明显高于β-TCP组（P < 0.05）。虽然这项研究有局限性，但研究结果显示了CO 3Ap在犬单壁骨下缺损牙周再生中的安全性和有效性，并且CO 3Ap与骨结合的能力优于β-TCP。CO 3Ap是一种生物可吸收骨移植材料。CO 3Ap组可见新骨、新牙骨质及牙周膜形成。CO 3Ap与骨的结合能力优于β-TCP。
This study aimed to histologically compare periodontal regeneration of one-wall intrabony defects treated with open flap debridement, β-tricalcium phosphate (β-TCP), and carbonate apatite (CO3Ap) in dogs. The mandibular third premolars of four beagle dogs were extracted. Twelve weeks after the extraction, a one-wall bone defect of 4 mm × 5 mm (mesio-distal width × depth) was created on the distal side of the mandibular second premolar and mesial side of the fourth premolar. Each defect was randomly allocated to open flap debridement (control group), periodontal regeneration utilizing β-TCP, or CO3Ap. Eight weeks after the surgery, histologic and histometric analyses were performed. No ankylosis, infection, or acute inflammation was observed at any of the experimental sites. Newly formed bone and cementum were observed in all experimental groups. The mineral apposition rate of the alveolar bone crest was higher in the CO3Ap group than in the control and β-TCP groups. The ratio of the new bone area was significantly higher in the CO3Ap group than in the control group (P < 0.05). The bone contact percentage of the residual granules was significantly higher in the CO3Ap group than in the β-TCP group (P < 0.05). Although this study has limitations, the findings revealed the safety and efficacy of CO3Ap for periodontal regeneration in one-wall intrabony defects in dogs, and CO3Ap has a better ability to integrate with bone than β-TCP. CO3Ap is a bioabsorbable bone graft material. In CO3Ap group, new bone, new cementum, and periodontal ligament formation were observed. CO3Ap has a better ability to integrate with bone than β-TCP.
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影响因子：
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作者：
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作者：
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