Zinc is decreased in prostate cancer: an established relationship of prostate cancer!
Zinc is decreased in prostate cancer: an established relationship of prostate cancer!
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DOI：
10.1007/s00775-010-0736-9
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发表时间：
2011-01
影响因子：
3
通讯作者：
Franklin, Renty B.
中科院分区：
文献类型：
--
作者：
Costello, Leslie C.;Franklin, Renty B.
这篇小综述是由Banas等人的最近报告（J Biol Inorg Chem 15：1147-1155，2010）引起的，该报告旨在显示并得出结论，前列腺癌中的锌水平增加。这一结论与过去约60年来大量报告中积累的压倒性临床和实验证据相冲突;这些证据一致表明前列腺锌水平在前列腺癌的发展和进展中降低。我们认为，这是前列腺癌中的一种既定关系，在任何旨在确定与这种既定关系不一致的结果的研究中必须考虑和描述。为了支持这种关系，我们提供了一个小审查的信息，导致建立这种关系。与大多数已建立的临床关系一样，经常存在例外和异常。然而，这些必须在既定关系的背景下描述和解释，而不是在反驳既定关系的背景下，至少在充分的确证证据推翻现有证据之前。这为解决和批评Banas等人的报告提供了背景。更广泛和更严重的影响是，临床和生物医学研究界普遍缺乏认识和/或缺乏认识，认为前列腺癌中锌减少是一种既定的关系。这导致了对临床、实验和流行病学问题的错误信息和误解，而这些问题并不符合科学、医学和公众的最佳利益。
This minireview is prompted by the recent report of Banas et al. (J Biol Inorg Chem 15:1147–1155, 2010), which purports to show and concludes that zinc levels are increased in prostate cancer. Such a conclusion conflicts with the overwhelming corroborating clinical and experimental evidence that has amassed from numerous reports over the past approximately 60 years; these consistently show that prostate zinc levels are decreased in the development and progression of prostate cancer. We submit that this is an established relationship in prostate cancer that must be considered and described in any studies that purport to identify results that are inconsistent with this established relationship. In support of this relationship, we provide a minireview of the information that has led to the establishment of this relationship. As with most established clinical relationships, exceptions and anomalies often exist. However, these must be described and explained in the context of the established relationship, and not in the context of refutation of the established relationship, at least not until sufficient corroborating evidence overwhelms the existing evidence. This provides a background to address and to critique the report of Banas et al. Of broader and more serious implications are the widespread recalcitrance and/or lack of knowledge within the clinical and biomedical research community for recognition that zinc decrease in prostate cancer is an established relationship. This leads to misinformation and misinterpretations regarding clinical, experimental, and epidemiological issues that do not serve the best interests of the scientific, medical, and public communities.
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影响因子：
37.3
作者：
Costello, Leslie C;Franklin, Renty B
通讯作者：
Franklin, Renty B
影响因子：
3.5
作者：
Cortesi, M.;Chechik, R.;Fridman, E.
通讯作者：
Fridman, E.
影响因子：
7.3
作者：
Yaman, M;Atici, D;Akdeniz, I
通讯作者：
Akdeniz, I
影响因子：
4.8
作者：
Johnson, Leslie A.;Kanak, Mazhar A.;Bagasra, Omar
通讯作者：
Bagasra, Omar
DOI：
10.1139/cjms52-043
发表时间：
1952-01-01
期刊：
CANADIAN JOURNAL OF MEDICAL SCIENCES
影响因子：
--
作者：
MAWSON, CA;FISCHER, MI
通讯作者：
FISCHER, MI