Efficacy of P188 on lapine meniscus preservation following blunt trauma.
Efficacy of P188 on lapine meniscus preservation following blunt trauma.
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钝性创伤后，P188对打衣弯月板保存的功效。
DOI：
10.1016/j.jmbbm.2015.03.008
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发表时间：
2015-07
影响因子：
3.9
通讯作者：
Donahue, Tammy L. Haut
中科院分区：
文献类型：
--
作者：
Coatney, Garrett A.;Abraham, Adam C.;Fischenich, Kristine M.;Button, Keith D.;Haut, Roger C.;Donahue, Tammy L. Haut
膝关节的创伤性损伤导致创伤后骨关节炎的发展。本研究的目的是表征单次关节内注射非离子型表面活性剂泊洛沙姆188（P188）通过维持关节糖胺聚糖（GAG）含量和机械性能来保护创伤后关节组织的作用。对Flemish Giant兔进行闭合膝关节、创伤性压缩冲击，关节受到限制以防止胫骨前平移。对侧肢体作为未受影响的对照。6只动物（治疗组）在创伤后接受磷酸盐缓冲盐水（PBS）中的P188注射，另外6只动物（假手术组）接受对受影响肢体的PBS单次注射。创伤后6周确定GAG的组织学分析，并使用应力松弛微压痕评估功能结果。假手术组的阻生肢表现出与非阻生肢相比，坐骨神经GAG覆盖率显著降低（p < 0.05）。在所有区域中，除了内侧前部之外，P188治疗的嵌顿肢体的GAG覆盖率与对侧非嵌顿肢体没有显著差异（p < 0.05）。与其各自的对照肢体相比，假手术组或给药组的力学均未记录显著变化。这表明P188的单次关节内注射显示出预防创伤诱导的GAG损失的前景。
Traumatic injury to the knee leads to the development of posttraumatic osteoarthritis. The objective of this study was to characterize the effects of a single intra-articular injection of a non-ionic surfactant, Poloxamer 188 (P188), in preservation of meniscal tissue following trauma through maintenance of meniscal glycosaminoglycan (GAG) content and mechanical properties. Flemish Giant rabbits were subjected to a closed knee joint, traumatic compressive impact with the joint constrained to prevent anterior tibial translation. The contralateral limb served as an un-impacted control. Six animals (treated) received an injection of P188 in phosphate buffered saline (PBS) post trauma, and another six animals (sham) received a single injection of PBS to the impacted limb. Histological analyses for GAG was determined 6 weeks post trauma, and functional outcomes were assessed using stress relaxation micro-indentation. The impacted limbs of the sham group demonstrated a significant decrease in meniscal GAG coverage compared to non-impacted limbs (p < 0.05). GAG coverage of the impacted P188 treated limbs was not significantly different than contralateral non-impacted limbs in all regions except the medial anterior (p < 0.05). No significant changes were documented in mechanics for either the sham or treated groups compared to their respective control limbs. This suggests that a single intra-articular injection of P188 shows promise in prevention of trauma induced GAG loss.
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影响因子：
3.5
作者：
Lin, David C.;Shreiber, David I.;Dimitriadis, Emilios K.;Horkay, Ferenc
通讯作者：
Horkay, Ferenc
DOI：
10.1115/1.4027468
发表时间：
2014-07-01
影响因子：
1.7
作者：
Fischenich, Kristine M.;Coatney, Garrett A.;Donahue, Tammy L. Haut
通讯作者：
Donahue, Tammy L. Haut
影响因子：
3.4
作者：
Maskarinec, SA;Hannig, J;Lee, KYC
通讯作者：
Lee, KYC
影响因子：
3.9
作者：
Kisiday, John D.;Vanderploeg, Eric J.;Frisbie, David D.
通讯作者：
Frisbie, David D.
影响因子：
2.3
作者：
Bajaj, Sarvottam;Shoemaker, Thomas;Chubinskaya, Susan
通讯作者：
Chubinskaya, Susan