Sex differences in risk factors of uncomplicated colonic diverticulosis in a metropolitan area from Northern China.
Sex differences in risk factors of uncomplicated colonic diverticulosis in a metropolitan area from Northern China.
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中国北方大城市地区单纯性结肠憩室病危险因素的性别差异
DOI：
10.1038/s41598-017-18517-1
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发表时间：
2018-01-09
影响因子：
4.6
通讯作者：
Sun C
中科院分区：
文献类型：
--
作者：
Yang F;Zheng Y;Jiang X;Su Z;Wang Y;Lin L;Lv H;Zhang J;Zhao J;Wang B;Jiang K;Sun C
作为世界上人口最多、老龄化速度最快的国家，中国在非复杂性结肠憩室病发病因素方面的性别差异信息有限。本研究旨在探讨北方某大都市人群个体危险因素的性别差异。对接受结肠镜检查的结肠憩室病患者的病史和人口学特征进行询问。从前瞻性数据集中检索人口统计信息、生活方式因素和合并症。采用多元回归分析确定憩室的诱发因素。4386例患者中检出结肠憩室218例(4.97%)。多因素Logistic回归分析显示年龄(OR = 1.05，95%CI 1.03~1.06，P <； 0.001)、红肉≥100 g/d(OR = 2.53，95%CI 1.72~3.70，P <； 0.001)、吸烟(OR = 2.14，95%CI 1.05~4.33，P = 0.035)、风湿性疾病(OR = 3.38，95%CI 1.09~10.5，P = 0.035)和非甾体抗炎药(OR = 2.11，95%CI 1.12~3.97，P = 0.020)与男性憩室病显著相关，同时年龄增大(OR = 1.03，95%CI 1.01~1.05，P = 0.013)、体重指数(OR = 1.12，95%CI 1.04~1.19，P = 0.001)、吸烟(OR = 10.2，95%CI 2.81~37.4，P <； 0.001)、风湿病(OR = 8.04，95%CI 3.05-21.2，P <； 0.001)、高血压(OR = 1.76，95%CI 1.01-3.06，P = 0.047)、结肠息肉(OR = 3.12，95%CI 1.82-5.36，P <； 0.001)和降压药物(OR = 2.99，95%CI 1.66-5.39，P <； 0.001)。总而言之，在非复杂性结肠憩室病的发展过程中，考虑不同的性别相关因素是至关重要的。
As the world’s most populated and rapidly aging country, there is limited information on sex-related differences in factors regarding uncomplicated colonic diverticulosis in China. We aimed to investigate sex differences in individual risk factor in a northern metropolis. Patients with colonic diverticulosis who underwent indicated colonoscopy were queried with respect to medical history and demographic features. Demographic information, life style factors and co-morbidities were retrieved from a prospective dataset. Multiple regression analyses were performed to determine precipitating factors of diverticula. Of 4,386 enrolled patients, colonic diverticulosis were detected in 218 cases (4.97%). Multiple logistic regression analysis implicated increasing age (OR = 1.05, 95%CI 1.03–1.06, P < 0.001), red meat ≥100 g/d (OR = 2.53, 95%CI 1.72–3.70, P < 0.001), smoking (OR = 2.14, 95%CI 1.05–4.33, P = 0.035), rheumatologic diseases (OR = 3.38, 95%CI 1.09–10.5, P = 0.035) and NSAIDs (OR = 2.11, 95%CI 1.12–3.97, P = 0.020) were significantly associated with diverticulosis in men, whilst advancing age (OR = 1.03, 95%CI 1.01–1.05, P = 0.013), BMI (OR = 1.12, 95%CI 1.04–1.19, P = 0.001), smoking (OR = 10.2, 95%CI 2.81–37.4, P < 0.001), rheumatologic diseases (OR = 8.04, 95%CI 3.05–21.2, P < 0.001), hypertension (OR = 1.76, 95%CI 1.01–3.06, P = 0.047), colonic polyps (OR = 3.12, 95%CI 1.82–5.36, P < 0.001) and antihypertensive medications (OR = 2.99, 95%CI 1.66–5.39, P < 0.001) in women. In conclusion, it is pivotal to take account of differentially sex-related factors in regard to the development of uncomplicated colonic diverticulosis.
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影响因子：
3.7
作者：
Nagata N;Niikura R;Shimbo T;Kishida Y;Sekine K;Tanaka S;Aoki T;Watanabe K;Akiyama J;Yanase M;Itoh T;Mizokami M;Uemura N
通讯作者：
Uemura N
影响因子：
3.7
作者：
Yamamichi N;Shimamoto T;Takahashi Y;Sakaguchi Y;Kakimoto H;Matsuda R;Kataoka Y;Saito I;Tsuji Y;Yakabi S;Takeuchi C;Minatsuki C;Niimi K;Asada-Hirayama I;Nakayama C;Ono S;Kodashima S;Yamaguchi D;Fujishiro M;Yamaji Y;Wada R;Mitsushima T;Koike K
通讯作者：
Koike K
影响因子：
3.9
作者：
McConnell, EJ;Tessier, DJ;Wolff, BG
通讯作者：
Wolff, BG
影响因子：
24.5
作者：
Barbara, Giovanni;Scaioli, Eleonora;Festi, Davide
通讯作者：
Festi, Davide
DOI：
10.1073/pnas.0504978102
发表时间：
2005-08-02
影响因子：
11.1
作者：
Ley, RE;Bäckhed, F;Gordon, JI
通讯作者：
Gordon, JI