Alcohol and smoking affect risk of uncomplicated colonic diverticulosis in Japan.
Alcohol and smoking affect risk of uncomplicated colonic diverticulosis in Japan.
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DOI：
10.1371/journal.pone.0081137
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Uemura N
中科院分区：
文献类型：
--
作者：
Nagata N;Niikura R;Shimbo T;Kishida Y;Sekine K;Tanaka S;Aoki T;Watanabe K;Akiyama J;Yanase M;Itoh T;Mizokami M;Uemura N
结肠憩室在亚洲主要位于右侧，在欧洲和美国主要位于左侧。与单纯性结肠憩室病相关的因素及其分布模式尚不清楚。我们的目的是调查单纯性结肠憩室病的患病率和危险因素。我们对接受结肠镜检查的成年人进行了一项前瞻性横断面研究。在结肠镜检查当天通过访谈评估酒精、酒精相关潮红、吸烟、药物和合并症。饮酒量分为不饮酒者、轻度（1-180 g/周）、中度（181-360 g/周）和重度（≥361 g/周）。吸烟指数定义为每天吸烟数量乘以吸烟年数，并分为不吸烟者、<400、400-799和≥800。共有2，164例连续患者入组。总体而言，542例患者（25.1%）患有右侧（50%）、双侧（29%）和左侧（21%）的无并发症结肠憩室病。单因素分析显示，年龄、男性、吸烟指数、饮酒、阿司匹林使用、抗凝剂使用、皮质类固醇使用、高血压和动脉粥样硬化性疾病是与憩室病显著相关的因素。与酒精相关的潮红与疾病无关。多因素分析显示年龄增加（P<0.01）、饮酒量增加（P<0.01）、吸烟（P <0.01）、动脉粥样硬化（P<0.01）是冠心病的显著相关因素。酒精和吸烟与右侧和双侧憩室有关。总之，四分之一的日本成年人患有结肠憩室病（50%右侧）。年龄、饮酒和吸烟是单纯性结肠憩室病的重要危险因素，尤其是右侧和双侧。
Colonic diverticula are located predominantly on the right side in Asia and on the left side in Europe and the United States. Factors associated with uncomplicated colonic diverticulosis and its distribution pattern have been unknown. Our aims are to investigate the prevalence and risk factors for uncomplicated colonic diverticulosis. We conducted a prospective cross-sectional study in adults who underwent colonoscopy. Alcohol, alcohol related flushing, smoking, medications, and comorbidities were assessed by interview on the colonoscopy day. Alcohol consumption was categorized as nondrinker, light (1–180 g/week), moderate (181–360 g/week), and heavy (≥361 g/week). Smoking index was defined as the number of cigarettes per day multiplied by the number of smoking years and categorized as nonsmoker, <400, 400–799, and ≥800. A total of 2,164 consecutive patients were enrolled. Overall, 542 patients (25.1%) had uncomplicated colonic diverticulosis located on the right side (50%), bilaterally (29%), and on the left side (21%). Univariate analysis revealed age, male, smoking index, alcohol consumption, aspirin use, anticoagulants use, corticosteroid use, hypertension, and atherosclerotic disease as factors significantly associated with diverticulosis. Alcohol related flushing was not associated with the disease. Multivariate analysis showed increasing age (P<0.01), increasing alcohol consumption (P<0.01) and smoking (P<0.01), and atherosclerotic disease (P<0.01) as significantly associated factors. Alcohol and smoking were associated with right-sided and bilateral diverticula. In conclusion, one in four Japanese adults have colonic diverticulosis (50% right-sided). Age, alcohol consumption, and smoking were found to be significant risk factors for uncomplicated colonic diverticulosis, particularly right-sided and bilateral.
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影响因子：
3.2
作者：
Heise, Charles P.
通讯作者：
Heise, Charles P.
影响因子：
2.9
作者：
Martel, Jerry;Raskin, Jeffrey B.
通讯作者：
Raskin, Jeffrey B.
影响因子：
24.3
作者：
Miotto, D;Boschetto, P;Mapp, CE
通讯作者：
Mapp, CE
DOI：
10.3904/kjim.2010.25.2.140
发表时间：
2010-06
期刊：
The Korean journal of internal medicine
影响因子：
--
作者：
Song JH;Kim YS;Lee JH;Ok KS;Ryu SH;Lee JH;Moon JS
通讯作者：
Moon JS
影响因子：
3.9
作者：
NAKADA, I;UBUKATA, H;UMEDA, K
通讯作者：
UMEDA, K