Trend and risk factors of diverticulosis in Japan: age, gender, and lifestyle/metabolic-related factors may cooperatively affect on the colorectal diverticula formation.
Trend and risk factors of diverticulosis in Japan: age, gender, and lifestyle/metabolic-related factors may cooperatively affect on the colorectal diverticula formation.
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DOI：
10.1371/journal.pone.0123688
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Koike K
中科院分区：
文献类型：
--
作者：
Yamamichi N;Shimamoto T;Takahashi Y;Sakaguchi Y;Kakimoto H;Matsuda R;Kataoka Y;Saito I;Tsuji Y;Yakabi S;Takeuchi C;Minatsuki C;Niimi K;Asada-Hirayama I;Nakayama C;Ono S;Kodashima S;Yamaguchi D;Fujishiro M;Yamaji Y;Wada R;Mitsushima T;Koike K
尽管憩室病明显增加，但其危险因素尚未充分阐明。因此，我们的目标是确定与憩室病显著相关的因素。我们还旨在调查憩室病在日本的现状。我们回顾了1990年至2010年的医疗记录，其中包括日本普通人群中连续62503例无症状结肠镜检查者的数据。对最近3327名考生进行了16项背景因素分析。62503例（男性47325例，女性15178例，年龄52.1±9.2岁）中，11771例（18.8%，男性10023例，女性1748例）出现憩室病。1990-2000年和2001-2010年的憩室病发病率分别为13.0%（29,071人中有3,771人）和23.9%（33,432人中有8,000人）：在所有年龄组和男女中，后者都远高于前者。从结直肠憩室的解剖位置来看，左侧憩室随年龄明显增加，但随时间变化不明显。3,327例受试者的单因素分析显示，憩室病与4个基本因素（年龄、性别、体重指数、血压）、3个生活方式相关因素（吸烟、饮酒、成年后体重严重增加）和2个血液检查值（甘油三酯、糖化血红蛋白）有显著相关性。计算标准化系数（β）和比值比（OR）的多元logistic分析显示，年龄（β = 0.217-0.674, OR = 1.24-1.96）、男性（β = 0.185, OR = 1.20）、吸烟（β = 0.142-0.200, OR = 1.15-1.22）、成年期体重严重增加（β = 0.153, OR = 1.17）、糖化血红蛋白（β = 0.136, OR = 1.15）、饮酒（β = 0.109, OR = 1.11）、血清甘油三酯（β = 0.098, OR = 1.98）、糖尿病（β = 0.153, OR = 1.17）、糖尿病（β = 0.136, OR = 1.15）、糖尿病（β = 0.109, OR = 1.11）和糖尿病（β = 0.098, OR = 1.98）、糖尿病（β = 0.153, OR = 1.17）、糖尿病（β = 0.136, OR = 1.15）。OR = 1.10)与憩室病呈显著正相关，而体重指数和血压与憩室病无显著正相关。1990 - 2010年普通人群无症状结肠镜检查者的大规模资料显示，日本憩室病的患病率仍呈上升趋势。年龄、男性、吸烟、成年期体重严重增加、血清HbA1c、饮酒、血清甘油三酯与憩室病呈显著正相关。
Despite the marked increase of diverticulosis, its risk factors have not been adequately elucidated. We therefore aim to identify significantly associated factors with diverticulosis. We also aim to investigate the present state of diverticulosis in Japan. We reviewed the medical records from 1990 to 2010 that included the data of consecutive 62,503 asymptomatic colonoscopy examinees from the general population in Japan. Most recent 3,327 examinees were analyzed with 16 background factors. Among the 62,503 subjects (47,325 men and 15,178 women; 52.1 ± 9.2 years old), diverticulosis was detected in 11,771 subjects (18.8%; 10,023 men and 1,748 women). The incidences of diverticulosis in 1990-2000 and 2001-2010 were respectively 13.0% (3,771 of 29,071) and 23.9% (8,000 of 33,432): the latter was much higher than the former in all age groups and for both genders. Considering the anatomical locations of colorectal diverticula, left-sided ones have markedly increased with age but not significantly changed with times. Univariate analyses of the 3,327 subjects showed significant association of diverticulosis with four basic factors (age, sex, body mass index, blood pressure), three life style-related factor (smoking, drinking, severe weight increase in adulthood), and two blood test values (triglyceride, HbA1c). The multiple logistic analysis calculating standardized coefficients (β) and odds ratio (OR) demonstrated that age (β = 0.217-0.674, OR = 1.24-1.96), male gender (β = 0.185, OR = 1.20), smoking (β = 0.142-0.200, OR = 1.15-1.22), severe weight increase in adulthood (β = 0.153, OR = 1.17), HbA1c (β = 0.136, OR = 1.15), drinking (β = 0.109, OR = 1.11), and serum triglyceride (β = 0.098, OR = 1.10) showed significantly positive association with diverticulosis whereas body mass index and blood pressure did not. The large-scale data of asymptomatic colonoscopy examinees from the general population from 1990 to 2010 indicated that the prevalence of diverticulosis is still increasing in Japan. Age, male gender, smoking, severe weight increase in adulthood, serum HbA1c, drinking, and serum triglyceride showed significant positive association with diverticulosis.
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影响因子：
3.7
作者：
Minatsuki C;Yamamichi N;Shimamoto T;Kakimoto H;Takahashi Y;Fujishiro M;Sakaguchi Y;Nakayama C;Konno-Shimizu M;Matsuda R;Mochizuki S;Asada-Hirayama I;Tsuji Y;Kodashima S;Ono S;Niimi K;Mitsushima T;Koike K
通讯作者：
Koike K
影响因子：
9.6
作者：
Hjern, F.;Wolk, A.;Hakansson, N.
通讯作者：
Hakansson, N.
影响因子：
3.7
作者：
Nagata N;Niikura R;Shimbo T;Kishida Y;Sekine K;Tanaka S;Aoki T;Watanabe K;Akiyama J;Yanase M;Itoh T;Mizokami M;Uemura N
通讯作者：
Uemura N
影响因子：
3.2
作者：
Heise, Charles P.
通讯作者：
Heise, Charles P.
影响因子：
2.9
作者：
Martel, Jerry;Raskin, Jeffrey B.
通讯作者：
Raskin, Jeffrey B.