An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.
An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.
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DOI：
10.1038/s41598-018-31659-0
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发表时间：
2018-09-10
影响因子：
4.6
通讯作者：
McDermott U
中科院分区：
文献类型：
--
作者：
Collord G;Tarpey P;Kurbatova N;Martincorena I;Moran S;Castro M;Nagy T;Bignell G;Maura F;Young MD;Berna J;Tubio JMC;McMurran CE;Young AMH;Sanders M;Noorani I;Price SJ;Watts C;Leipnitz E;Kirsch M;Schackert G;Pearson D;Devadass A;Ram Z;Collins VP;Allinson K;Jenkinson MD;Zakaria R;Syed K;Hanemann CO;Dunn J;McDermott MW;Kirollos RW;Vassiliou GS;Esteller M;Behjati S;Brazma A;Santarius T;McDermott U
间变性脑膜瘤是一种罕见的侵袭性脑肿瘤，其特点是难治性复发和预后差。在此，我们对原发性和复发性间变性脑膜瘤的全基因组、转录组和甲基化谱进行了综合分析。一个关键发现是描绘了与完全相反的生存结果相关的不同分子亚组。相对于低级别脑膜瘤，间变性肿瘤在SWI/SNF复合体基因中携带频繁的驱动突变，仅限于预后不良的亚组。侵袭性疾病的进一步特征在于PRC 2活性增加、干性和上皮向间充质转化的转录证据。我们的分析辨别生物学上不同的变异间变性脑膜瘤的预后和治疗意义。
Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent anaplastic meningioma. A key finding was the delineation of distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. Aggressive disease was further characterised by transcriptional evidence of increased PRC2 activity, stemness and epithelial-to-mesenchymal transition. Our analyses discern biologically distinct variants of anaplastic meningioma with prognostic and therapeutic significance.
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影响因子：
4.6
作者：
Bernhart, Stephan H.;Kretzmer, Helene;Hoffmann, Steve
通讯作者：
Hoffmann, Steve
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
12.3
作者：
Buels R;Yao E;Diesh CM;Hayes RD;Munoz-Torres M;Helt G;Goodstein DM;Elsik CG;Lewis SE;Stein L;Holmes IH
通讯作者：
Holmes IH
DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
影响因子：
9
作者：
Bao X;Ren T;Huang Y;Sun K;Wang S;Liu K;Zheng B;Guo W
通讯作者：
Guo W