Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo.
Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo.
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DOI：
10.3892/or.2017.5766
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发表时间：
2017-08
期刊：
影响因子：
4.2
通讯作者：
Rezaee R
中科院分区：
文献类型：
--
作者：
Hashemzaei M;Delarami Far A;Yari A;Heravi RE;Tabrizian K;Taghdisi SM;Sadegh SE;Tsarouhas K;Kouretas D;Tzanakakis G;Nikitovic D;Anisimov NY;Spandidos DA;Tsatsakis AM;Rezaee R
本研究的重点是阐明槲皮素的假定抗癌潜力。通过 MMT 测定在 9 种肿瘤细胞系（结肠癌 CT-26 细胞、前列腺腺癌 LNCaP 细胞、人前列腺 PC3 细胞、嗜铬细胞瘤 PC12 细胞、雌激素受体阳性乳腺癌 MCF-7 细胞、急性淋巴细胞 白血病 MOLT-4 T 细胞、人骨髓瘤 U266B1 细胞、人淋巴 Raji 细胞和卵巢癌 CHO 细胞）。发现槲皮素在所用浓度下可诱导所有测试的癌细胞系凋亡。此外，Annexin V/PI染色显示，与对照组相比，槲皮素显着诱导CT-26、LNCaP、MOLT-4和Raji细胞系的凋亡（P<0.001）。在体内实验中，与对照组相比，携带MCF-7和CT-26肿瘤的小鼠在槲皮素治疗组中表现出肿瘤体积显着减小（P<0.001）。总而言之，槲皮素是一种天然存在的化合物，在体内和体外均表现出抗癌特性。
The present study focused on the elucidation of the putative anticancer potential of quercetin. The anticancer activity of quercetin at 10, 20, 40, 80 and 120 µM was assessed in vitro by MMT assay in 9 tumor cell lines (colon carcinoma CT-26 cells, prostate adenocarcinoma LNCaP cells, human prostate PC3 cells, pheocromocytoma PC12 cells, estrogen receptor-positive breast cancer MCF-7 cells, acute lymphoblastic leukemia MOLT-4 T-cells, human myeloma U266B1 cells, human lymphoid Raji cells and ovarian cancer CHO cells). Quercetin was found to induce the apoptosis of all the tested cancer cell lines at the utilized concentrations. Moreover, quercetin significantly induced the apoptosis of the CT-26, LNCaP, MOLT-4 and Raji cell lines, as compared to control group (P<0.001), as demonstrated by Annexin V/PI staining. In in vivo experiments, mice bearing MCF-7 and CT-26 tumors exhibited a significant reduction in tumor volume in the quercetin-treated group as compared to the control group (P<0.001). Taken together, quercetin, a naturally occurring compound, exhibits anticancer properties both in vivo and in vitro.
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影响因子：
2.8
作者：
Chien, Su-Yu;Wu, Yao-Chung;Chen, Dar-Ren
通讯作者：
Chen, Dar-Ren
DOI：
10.1093/ecam/neq053
发表时间：
2011
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Gibellini L;Pinti M;Nasi M;Montagna JP;De Biasi S;Roat E;Bertoncelli L;Cooper EL;Cossarizza A
通讯作者：
Cossarizza A
影响因子：
4.4
作者：
Castle JC;Loewer M;Boegel S;de Graaf J;Bender C;Tadmor AD;Boisguerin V;Bukur T;Sorn P;Paret C;Diken M;Kreiter S;Türeci Ö;Sahin U
通讯作者：
Sahin U
负载阿霉素的二氧化硅纳米摇铃积极寻找具有改善抗肿瘤效果的肿瘤
影响因子：
6.7
作者：
Gao, Fuping;Li, Linlin;Tang, Fangqiong
通讯作者：
Tang, Fangqiong
影响因子：
5.7
作者：
Busch C;Burkard M;Leischner C;Lauer UM;Frank J;Venturelli S
通讯作者：
Venturelli S