Epigenetic activities of flavonoids in the prevention and treatment of cancer.
Epigenetic activities of flavonoids in the prevention and treatment of cancer.
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DOI：
10.1186/s13148-015-0095-z
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发表时间：
2015
影响因子：
5.7
通讯作者：
Venturelli S
中科院分区：
文献类型：
--
作者：
Busch C;Burkard M;Leischner C;Lauer UM;Frank J;Venturelli S
越来越多的病理状况描述了异常的表观遗传修饰，包括神经退行性疾病、心血管疾病、2 型糖尿病、肥胖和癌症。表观遗传变化的一般可逆性使它们成为有吸引力且有前途的目标，例如在癌症的治疗中。因此，目前正在临床试验中测试越来越多的表观遗传活性化合物的治疗潜力。有趣的是，植物性食品中存在的许多植物化学物质，特别是类黄酮，被认为能够改变表观遗传细胞机制。黄酮类化合物是天然的酚类化合物，形成一大类具有有趣生物活性的植物次生代谢物。它们可分为六个主要亚类，这些亚类表现出不同的特性，影响两个最有特征的表观遗传机制：DNA 甲基化状态和组蛋白乙酰化的调节。大量流行病学研究强烈表明，高饮食黄酮类化合物摄入量可以降低多种癌症的风险。富含水果和蔬菜的饮食具有既定的健康促进作用，但使用纯化的类黄酮作为补充剂或药物的努力面临着挑战，因此有关后者应用的数据仍然存在争议。本综述的目的是概述当前黄酮类化合物的研究，以进一步阐明其在癌症预防和治疗方面的潜力，从而重点关注其独特的表观遗传活性。
Aberrant epigenetic modifications are described in an increasing number of pathological conditions, including neurodegenerative diseases, cardiovascular diseases, diabetes mellitus type 2, obesity and cancer. The general reversibility of epigenetic changes makes them an attractive and promising target e.g. in the treatment of cancer. Thus, a growing number of epigenetically active compounds are currently tested in clinical trials for their therapeutic potential. Interestingly, many phytochemicals present in plant foods, particularly flavonoids, are suggested to be able to alter epigenetic cellular mechanisms. Flavonoids are natural phenol compounds that form a large group of secondary plant metabolites with interesting biological activities. They can be categorized into six major subclasses, which display diverse properties affecting the two best characterized epigenetic mechanisms: modulation of the DNA methylation status and histone acetylation. High dietary flavonoid intake has strongly been suggested to reduce the risk of numerous cancer entities in a large body of epidemiological studies. Established health-promoting effects of diets rich in fruit and vegetables are faced by efforts to use purified flavonoids as supplements or pharmaceuticals, whereupon data on the latter applications remain controversial. The purpose of this review is to give an overview of current research on flavonoids to further elucidate their potential in cancer prevention and therapy, thereby focusing on their distinct epigenetic activities.
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DOI：
10.3945/ajcn.114.088708
发表时间：
2014-11
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Cassidy A;Huang T;Rice MS;Rimm EB;Tworoger SS
通讯作者：
Tworoger SS
影响因子：
6.4
作者：
Bairati, Isabelle;Meyer, Francois;Tetu, Bernard
通讯作者：
Tetu, Bernard
影响因子：
4.2
作者：
Brat, Pierre;George, Stephane;Amiot, Marie Josephe
通讯作者：
Amiot, Marie Josephe
DOI：
10.1158/1078-0432.ccr-08-2332
发表时间：
2009-03-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Adhami VM;Siddiqui IA;Sarfaraz S;Khwaja SI;Hafeez BB;Ahmad N;Mukhtar H
通讯作者：
Mukhtar H
影响因子：
6.1
作者：
Arabbi, PR;Genovese, MI;Lajolo, FM
通讯作者：
Lajolo, FM