Highly pathogenic avian influenza A (H5N1) in marine mammals and seabirds in Peru.
Highly pathogenic avian influenza A (H5N1) in marine mammals and seabirds in Peru.
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DOI：
10.1038/s41467-023-41182-0
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发表时间：
2023-09-07
影响因子：
16.6
通讯作者：
Lescano, Jesus
中科院分区：
文献类型：
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作者：
Leguia, Mariana;Garcia-Glaessner, Alejandra;Munoz-Saavedra, Breno;Juarez, Diana;Barrera, Patricia;Calvo-Mac, Carlos;Jara, Javier;Silva, Walter;Ploog, Karl;Amaro, Lady;Colchao-Claux, Paulo;Johnson, Christine K.;Uhart, Marcela M.;Nelson, Martha I.;Lescano, Jesus
高致病性禽流感（HPAI）A/H5 N1病毒（谱系2.3.4.4b）正在迅速入侵美洲，威胁野生动物和家禽，并可能演变为下一次全球大流行。于二零二二年十一月，高致病性禽流感抵达秘鲁，引发大规模派力肯及海狮死亡。我们报告了五种海洋哺乳动物和海鸟（海豚，海狮，Sanderlings，鹈鹕和鸬鹚）的HPAI/H5 N1的基因组特征。秘鲁病毒属于谱系2.3.4.4b，但它们是4：4重组体，其中4个基因组片段（PA、HA、NA和MP）位于最初从欧亚大陆进入北美的欧亚谱系内，而其他4个基因组片段（PB 2、PB 1、NP和NS）位于在北美传播的美洲谱系（C支）内。这些病毒正在迅速积累突变，包括令人关切的突变，需要进一步检查，并强调迫切需要积极的地方监测，以管理疫情并限制向包括人类在内的其他物种蔓延。高致病性禽流感（HPAI）A/H5 N1最近在美洲出现，并与鹈鹕和海狮的大规模死亡事件有关。在这里，作者报告了从秘鲁的五种海洋哺乳动物和海鸟中采集的高致病性禽流感A/H5 N1基因组的样本和特征。
Highly pathogenic avian influenza (HPAI) A/H5N1 viruses (lineage 2.3.4.4b) are rapidly invading the Americas, threatening wildlife, poultry, and potentially evolving into the next global pandemic. In November 2022 HPAI arrived in Peru, triggering massive pelican and sea lion die-offs. We report genomic characterization of HPAI/H5N1 in five species of marine mammals and seabirds (dolphins, sea lions, sanderlings, pelicans and cormorants). Peruvian viruses belong to lineage 2.3.4.4b, but they are 4:4 reassortants where 4 genomic segments (PA, HA, NA and MP) position within the Eurasian lineage that initially entered North America from Eurasia, while the other 4 genomic segments (PB2, PB1, NP and NS) position within the American lineage (clade C) that circulated in North America. These viruses are rapidly accruing mutations, including mutations of concern, that warrant further examination and highlight an urgent need for active local surveillance to manage outbreaks and limit spillover into other species, including humans. Highly pathogenic avian influenza (HPAI) A/H5N1 has recently emerged in the Americas and has been implicated in mass die-off events of pelicans and sea lions. Here, the authors report sampling and characterisation of HPAI A/H5N1 genomes from five marine mammal and seabird species in Peru.
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