Gene Expression and Epigenetic Signatures of Germ Cell-Derived Pluripotent Stem Cells and Embryonic Stem Cells

Gene Expression and Epigenetic Signatures of Germ Cell-Derived Pluripotent Stem Cells and Embryonic Stem Cells
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生殖细胞来源的多能干细胞和胚胎干细胞的基因表达和表观遗传特征

DOI:
10.1007/978-94-007-2993-3_3
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发表时间:
2012
期刊:
影响因子:
--
通讯作者:
Zechner U.
Zechner U.
中科院分区:
--
文献类型:
--
作者:
Nolte J;Pantakani D.V;Dihazi H;Zechner U.

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生殖细胞来源的多能干细胞(GPSCs)是来源于睾丸的精原干细胞(Sscs)的多潜能干细胞。最近几年的一些报道表明,通过不同的方法分离和丰富SSC群体是可能的,甚至可以在体外将这些SSC重新编程为gPSC。由于这些细胞可能是一种绕过使用胚胎干细胞(ESCs)用于治疗方法的伦理反对意见的替代方案,这些来自SSC的gPSCs在几项研究中与多能性的黄金标准ESCs进行了比较。这一结果为gPSCs在再生医学中的实际应用提供了很好的前景。
Germ cell-derived Pluripotent Stem Cells (gPSCs) are pluripotent stem cells that originate from Spermatogonial Stem Cells (SSCs) of the testis. Several reports in the last few years have shown that it is possible to isolate and enrich the SSC population by different approaches and even reprogram thesein vivomultipotent cells to gPSCsin vitro. As these cells could be an alternative to circumvent the ethical objections regarding the use of Embryonic Stem Cells (ESCs) for therapeutic approaches, these SSC-derived gPSCs were characterized in several studies comparatively to the gold standard of pluripotency, the ESCs. The results provide great promise that gPSCs can be of importance for practical use in regenerative medicine.
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