Gene Expression and Epigenetic Signatures of Germ Cell-Derived Pluripotent Stem Cells and Embryonic Stem Cells
Gene Expression and Epigenetic Signatures of Germ Cell-Derived Pluripotent Stem Cells and Embryonic Stem Cells
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生殖细胞来源的多能干细胞和胚胎干细胞的基因表达和表观遗传特征
DOI:
10.1007/978-94-007-2993-3_3
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发表时间:
2012
期刊:
影响因子:
--
通讯作者:
Zechner U.
中科院分区:
文献类型:
--
作者:
Nolte J;Pantakani D.V;Dihazi H;Zechner U.
Germ cell-derived Pluripotent Stem Cells (gPSCs) are pluripotent stem cells that originate from Spermatogonial Stem Cells (SSCs) of the testis. Several reports in the last few years have shown that it is possible to isolate and enrich the SSC population by different approaches and even reprogram thesein vivomultipotent cells to gPSCsin vitro. As these cells could be an alternative to circumvent the ethical objections regarding the use of Embryonic Stem Cells (ESCs) for therapeutic approaches, these SSC-derived gPSCs were characterized in several studies comparatively to the gold standard of pluripotency, the ESCs. The results provide great promise that gPSCs can be of importance for practical use in regenerative medicine.
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影响因子:
4.8
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通讯作者:
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影响因子:
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