Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women.
Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women.
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DOI：
10.1016/j.appet.2009.09.011
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发表时间：
2010-02
期刊：
影响因子：
5.4
通讯作者：
Steinle, Nanette I.
中科院分区：
文献类型：
--
作者：
Dotson, Cedrick D.;Shaw, Hillary L.;Mitchell, Braxton D.;Munger, Steven D.;Steinle, Nanette I.
关键词：
对味觉化合物6-n-丙基硫氧嘧啶（PROP）的不敏感性已被认为是影响食物偏好和摄入的味觉个体差异的标志。PROP味觉敏感性表型变异的主要遗传决定因素是TAS 2 R38基因的等位基因，该基因编码对硫脲化合物（包括PROP和苯硫脲）敏感的化学感受受体。TAS 2 R家族的成员在味觉系统中表达，在味觉系统中它们作为苦味受体发挥作用，并且在整个肠道中表达，在肠道中它们在膳食、肠道源性激素释放中的生理作用开始被阐明。为了更好地了解TAS 2 R功能与摄食行为之间的关系，我们询问TAS 2 R38变体是否与三种饮食行为中的一种或多种相关：抑制，去抑制和饥饿。我们在Amish家族糖尿病研究中对729名非糖尿病个体（381名女性，348名男性）的TAS 2 R38基因rs 1726866（T785 C，Val 262 Ala）进行了单核苷酸多态性（SNP）基因分型。饮食行为进行了评估，使用三因素饮食问卷。rs 1726866和这三个性状之间的关联分析揭示了PROP不敏感的“T”等位基因与去抑制增加的显著关联（p = 0.03）。由于男性和女性之间的饮食行为差异很大，我们随后进行了性别分层分析，这表明女性（p = 0.0002），但男性没有很强的关联。与rs 1726866密切接近的其他SNP的分析表明，该位点是主要负责的协会。因此，我们的研究结果表明，TAS 2 R38的多态性与摄食行为的差异有关。
Insensitivity to the bitter-tasting compound 6-n-propylthiouracil (PROP) has been proposed as a marker for individual differences in taste perception that influence food preference and intake. The principal genetic determinants of phenotypic variation in PROP taste sensitivity are alleles of the TAS2R38 gene, which encodes a chemosensory receptor sensitive to thiourea compounds including PROP and phenylthiocarbamide. Members of the TAS2R family are expressed in the gustatory system, where they function as bitter taste receptors, and throughout the gut, where their physiological roles in prandial, gut-derived hormone release are beginning to be elucidated. To better understand the relationship between TAS2R function and ingestive behaviors, we asked if TAS2R38 variants are associated with one or more of three eating behaviors: restraint, disinhibition, and hunger. We genotyped a single nucleotide polymorphism (SNP) located within the TAS2R38 gene, rs1726866 (T785C, Val262Ala) in 729 nondiabetic individuals (381 females, 348 males) within the Amish Family Diabetes Study. Eating behaviors were assessed using the Three-Factor Eating Questionnaire. An association analysis between rs1726866 and these three traits revealed a significant association of the PROP-insensitive “T” allele with increased disinhibition (p = 0.03). Because eating behaviors differ substantially between males and females, we subsequently performed sex-stratified analyses, which revealed a strong association in females (p = 0.0002) but not in males. Analyses with other SNPs in close proximity to rs1726866 suggest that this locus is principally responsible for the association. Therefore, our results indicate that a polymorphism in TAS2R38 is associated with differences in ingestive behavior.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1016/s0002-8223(00)00191-7
发表时间：
2000-06-01
影响因子：
--
作者：
Duffy, VB;Bartoshuk, LM
通讯作者：
Bartoshuk, LM
DOI：
10.1073/pnas.87.19.7777
发表时间：
1990-10-01
影响因子：
11.1
作者：
AMES, BN;PROFET, M;GOLD, LS
通讯作者：
GOLD, LS
影响因子：
--
作者：
Drewnowski, Adam;Henderson, Susan A.;Cockroft, Jennie E.
通讯作者：
Cockroft, Jennie E.
影响因子：
56.9
作者：
Gabriel, SB;Schaffner, SF;Altshuler, D
通讯作者：
Altshuler, D