Cortical abnormalities and identification for first-episode schizophrenia via high-resolution magnetic resonance imaging
Cortical abnormalities and identification for first-episode schizophrenia via high-resolution magnetic resonance imaging
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通过高分辨率磁共振成像识别首发精神分裂症的皮质异常和识别
DOI：
10.1101/2020.02.05.20020768
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发表时间：
2020-02
影响因子：
--
通讯作者：
Qin Wei
中科院分区：
文献类型：
--
作者：
Liu Lin;Cui Long-Biao;Wu Xu-Sha;Fei Ning-Bo;Xu Zi-Liang;Wu Di;Xi Yi-Bin;Huang Peng;von Deneen Karen M.;Qi Shun;Zhang Ya-Hong;Wang Hua-Ning;Yin Hong;Qin Wei
Evidence from neuroimaging has implicated abnormal cerebral cortical patterns in schizophrenia. Application of machine learning techniques is required for identifying structural signature reflecting neurobiological substrates of schizophrenia at the individual level. We aimed to detect and develop a method for potential marker to identify schizophrenia via the features of cerebral cortex using high-resolution magnetic resonance imaging (MRI).In this study, cortical features were measured, including volumetric (cortical thickness, surface area, and gray matter volume) and geometric (mean curvature, metric distortion, and sulcal depth) features. Patients with first-episode schizophrenia (n = 52) and healthy controls (n = 66) were included from the Department of Psychiatry at Xijing Hospital. Multivariate computation was used to examine the abnormalities of cortical features in schizophrenia. Features were selected by least absolute shrinkage and selection operator (LASSO) method. The diagnostic capacity of multi-dimensional neuroanatomical patterns-based classification was evaluated based on diagnostic tests.Mean curvature (left insula and left inferior frontal gyrus), cortical thickness (left fusiform gyrus), and metric distortion (left cuneus and right superior temporal gyrus) revealed both group differences and diagnostic capacity. Area under receiver operating characteristic curve was 0.88, and the sensitivity, specificity, and accuracy of were 94%, 82%, and 88%, respectively. Confirming these findings, similar results were observed in the independent validation. There was a positive association between index score derived from the multi-dimensional patterns and the severity of symptoms (r = 0.40, P < .01) for patients.Our findings demonstrate a view of cortical differences with capacity to discriminate between patients with schizophrenia and healthy population. Structural neuroimaging-based measurements hold great promise of paving the road for their clinical utility in schizophrenia.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
DOI：
10.1016/s0140-6736(15)01121-6
发表时间：
2016-07-02
期刊：
Lancet (London, England)
影响因子：
--
作者：
Owen MJ;Sawa A;Mortensen PB
通讯作者：
Mortensen PB
影响因子：
4.6
作者：
Xu L;Qin W;Zhuo C;Liu H;Zhu J;Yu C
通讯作者：
Yu C
DOI：
10.1016/b978-0-12-813866-3.00038-2
发表时间：
2020
期刊：
Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease
影响因子：
--
作者：
D. Volk;Aaron K. Jenkins;Paven A. Lidstone;D. Lewis
通讯作者：
D. Volk;Aaron K. Jenkins;Paven A. Lidstone;D. Lewis
影响因子：
10.6
作者：
van Erp TGM;Walton E;Hibar DP;Schmaal L;Jiang W;Glahn DC;Pearlson GD;Yao N;Fukunaga M;Hashimoto R;Okada N;Yamamori H;Bustillo JR;Clark VP;Agartz I;Mueller BA;Cahn W;de Zwarte SMC;Hulshoff Pol HE;Kahn RS;Ophoff RA;van Haren NEM;Andreassen OA;Dale AM;Doan NT;Gurholt TP;Hartberg CB;Haukvik UK;Jørgensen KN;Lagerberg TV;Melle I;Westlye LT;Gruber O;Kraemer B;Richter A;Zilles D;Calhoun VD;Crespo-Facorro B;Roiz-Santiañez R;Tordesillas-Gutiérrez D;Loughland C;Carr VJ;Catts S;Cropley VL;Fullerton JM;Green MJ;Henskens FA;Jablensky A;Lenroot RK;Mowry BJ;Michie PT;Pantelis C;Quidé Y;Schall U;Scott RJ;Cairns MJ;Seal M;Tooney PA;Rasser PE;Cooper G;Shannon Weickert C;Weickert TW;Morris DW;Hong E;Kochunov P;Beard LM;Gur RE;Gur RC;Satterthwaite TD;Wolf DH;Belger A;Brown GG;Ford JM;Macciardi F;Mathalon DH;O'Leary DS;Potkin SG;Preda A;Voyvodic J;Lim KO;McEwen S;Yang F;Tan Y;Tan S;Wang Z;Fan F;Chen J;Xiang H;Tang S;Guo H;Wan P;Wei D;Bockholt HJ;Ehrlich S;Wolthusen RPF;King MD;Shoemaker JM;Sponheim SR;De Haan L;Koenders L;Machielsen MW;van Amelsvoort T;Veltman DJ;Assogna F;Banaj N;de Rossi P;Iorio M;Piras F;Spalletta G;McKenna PJ;Pomarol-Clotet E;Salvador R;Corvin A;Donohoe G;Kelly S;Whelan CD;Dickie EW;Rotenberg D;Voineskos AN;Ciufolini S;Radua J;Dazzan P;Murray R;Reis Marques T;Simmons A;Borgwardt S;Egloff L;Harrisberger F;Riecher-Rössler A;Smieskova R;Alpert KI;Wang L;Jönsson EG;Koops S;Sommer IEC;Bertolino A;Bonvino A;Di Giorgio A;Neilson E;Mayer AR;Stephen JM;Kwon JS;Yun JY;Cannon DM;McDonald C;Lebedeva I;Tomyshev AS;Akhadov T;Kaleda V;Fatouros-Bergman H;Flyckt L;Karolinska Schizophrenia Project;Busatto GF;Rosa PGP;Serpa MH;Zanetti MV;Hoschl C;Skoch A;Spaniel F;Tomecek D;Hagenaars SP;McIntosh AM;Whalley HC;Lawrie SM;Knöchel C;Oertel-Knöchel V;Stäblein M;Howells FM;Stein DJ;Temmingh HS;Uhlmann A;Lopez-Jaramillo C;Dima D;McMahon A;Faskowitz JI;Gutman BA;Jahanshad N;Thompson PM;Turner JA
通讯作者：
Turner JA