The highly expressed COL4A1 genes contributes to the proliferation and migration of the invasive ductal carcinomas.
The highly expressed COL4A1 genes contributes to the proliferation and migration of the invasive ductal carcinomas.
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高表达的COL4A1基因有助于浸润性导管癌的增殖和迁移
DOI：
10.18632/oncotarget.17345
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发表时间：
2017-08-29
期刊：
影响因子：
--
通讯作者：
Yu Z
中科院分区：
文献类型：
--
作者：
Jin R;Shen J;Zhang T;Liu Q;Liao C;Ma H;Li S;Yu Z
背景浸润性导管癌是一种非常典型的乳腺癌。本研究的目的是阐明浸润性导管癌的分子机制，寻找其潜在的治疗靶点。结果共识别出浸润性导管癌与正常乳腺上皮细胞差异表达基因478个。功能浓缩分析表明，大部分差异表达基因与细胞外基质-受体相互作用有关。在PPI网络中对这两个基因序列进行比对，找出其中最关键的两个基因miRNA调控网络，这可能有助于提高浸润性导管癌的治疗水平。此外，实验结果还表明，COL4A1基因在浸润性导管癌的增殖和集落形成中起重要作用。结论浸润性导管癌可能与ECM受体突变有关。这9个重要基因可能在浸润性导管癌的发生发展过程中起重要作用，可作为治疗靶点和预后指标。实验结果表明，COL4A1是影响乳腺浸润性癌细胞增殖和集落形成的关键基因之一。
Background Invasive ductal carcinoma is a kind of very typical breast cancer. The goal of our research was to figure out the molecular mechanism of Invasive ductal carcinoma and to find out its potential therapy targets. Results The total amount of 478 differentially expressed genes in Invasive ductal carcinoma which compared with normal breast epithelial cells were recognized. Functional enrichment analysis proved the most part of differentially expressed genes had connection with ECM-receptor interaction. The two genes lists were contrasted in PPI network, and miRNA regulation networks, The most two crucial genes were identified in our study, which may be helpful to improve Invasive ductal carcinoma treatment. Additionally, experimental results shows that the COL4A1 gene, one of identified genes, played important roles in both of proliferation and colony formation in Invasive ductal carcinoma. Conclusions Invasive ductal carcinoma could have connection with ECM-receptor mutations. These 9 vital genes could be an important part in the progression of Invasive ductal carcinoma and be offered as therapy targets and prognosis indicator. and the experimental results showed that one of the most crucial genes, COL4A1, was the key gene that influence the proliferation and colony formation of the Invasive ductal carcinoma cell.
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影响因子：
3.8
作者：
Turashvili, Gulisa;Bouchal, Jan;Baumforth, Karl;Wei, Wenbin;Dziechciarkova, Marta;Ehrmann, Jiri;Klein, Jiri;Fridman, Eduard;Skarda, Jozef;Srovnal, Josef;Hajduch, Marian;Murray, Paul;Kolar, Zdenek
通讯作者：
Kolar, Zdenek
影响因子：
2.9
作者：
Kuang J;Zhao M;Li H;Dang W;Li W
通讯作者：
Li W
影响因子：
4.4
作者：
Salem O;Erdem N;Jung J;Münstermann E;Wörner A;Wilhelm H;Wiemann S;Körner C
通讯作者：
Körner C
DOI：
10.1053/ejso.2002.1423
发表时间：
2003-05-01
期刊：
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
影响因子：
--
作者：
Mersin, H;Yildirim, E;Berberoglu, U
通讯作者：
Berberoglu, U
影响因子：
8.8
作者：
Toikkanen S;Pylkkänen L;Joensuu H
通讯作者：
Joensuu H