Activation of NPY receptors suppresses excitatory synaptic transmission in a taste-feeding network in the lower brain stem.
Activation of NPY receptors suppresses excitatory synaptic transmission in a taste-feeding network in the lower brain stem.
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NPY 受体的激活抑制下脑干味觉供给网络中的兴奋性突触传递。
DOI：
10.1152/ajpregu.00536.2011
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Travers,JosephB
中科院分区：
文献类型：
--
作者：
Chen,Zhixiong;Travers,SusanP;Travers,JosephB
Consummatory responses to taste stimuli are modulated by visceral signals processed in the caudal nucleus of the solitary tract (cNST) and ventrolateral medulla. On the basis of decerebrate preparations, this modulation can occur through local brain stem pathways. Among the large number of neuropeptides and neuromodulators implicated in these visceral pathways is neuropeptide Y (NPY), which is oftentimes colocalized in catecholaminergic neurons themselves implicated in glucoprivic-induced feeding and satiety. In addition to the cNST and ventrolateral medulla, noradrenergic and NPY receptors are found in circumscribed regions of the medullary reticular formation rich in preoromotor neurons. To test the hypothesis that NPY may act as a neuromodulator on preoromotor neurons, we recorded the effects of bath application of NPY and specific Y1 and Y2 agonists on currents elicited from electrical stimulation of the rostral (taste) NST in prehypoglossal neurons in a brain stem slice preparation. A high proportion of NST-driven responses were suppressed by NPY, as well as Y1 and Y2 agonists. On the basis of paired pulse ratios and changes in membrane resistance, we concluded that Y1 receptors influence these neurons both presynaptically and postsynaptically and that Y2 receptors have a presynaptic locus. To test the hypothesis that NPY may act in concert with norepinephrine (NE), we examined neurons showing suppressed responses in the presence of a Y2 agonist and demonstrated a greater degree of suppression to a Y2 agonist/NE cocktail. These suppressive effects on preoromotoneurons may reflect a satiety pathway originating from A2 neurons in the caudal brain stem.
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头端孤核和网状结构中的μ-阿片类药物调节改变了味觉反应性：对完成行为具有抑制作用的证据。
DOI：
10.1152/ajpregu.00142.2011
发表时间：
2011
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
--
作者：
Kinzeler,NicoleR;Travers,SusanP
通讯作者：
Travers,SusanP
胃肠道和代谢对膳食量控制的神经学分离。
影响因子：
1.9
作者：
Seeley,RJ;Grill,HJ;Kaplan,JM
通讯作者：
Kaplan,JM
大鼠下脑干和脊髓中的肽 YY (PYY)-免疫反应性神经元。
DOI：
10.1111/j.1748-1716.1985.tb07728.x
发表时间：
1985
期刊：
Acta physiologica Scandinavica
影响因子：
--
作者：
M. Broomé;T. Hökfelt;L. Terenius
通讯作者：
L. Terenius
DOI：
10.1152/ajpregu.90457.2008
发表时间：
2008-11-01
影响因子：
2.8
作者：
Nasse, J.;Terman, D.;Travers, J. B.
通讯作者：
Travers, J. B.
影响因子：
3
作者：
B. Stanley;S. E. Kyrkouli;Sharon Lampert;S. Leibowitz
通讯作者：
B. Stanley;S. E. Kyrkouli;Sharon Lampert;S. Leibowitz